Inventors:
John Wai - Harleysville PA, US
Boyoung Kim - Lansdale PA, US
Thorsten Fisher - Hatfield PA, US
Linghang Zhuang - Chalfont PA, US
Peter Williams - Harleysville PA, US
Terry Lyle - Lederach PA, US
H. Langford - Lansdale PA, US
Kyle Robinson - Philadelphia PA, US
International Classification:
A61P 31/18, A61K 39/21, C07D 471/00, C07D 487/00
US Classification:
424208100, 544350000, 544349000, 544336000
Abstract:
8,9-Dihydroxydihydropyridopyrazine-1,6-diones and 8,9-dihydroxypyridopyrazine-1,6-diones are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the pyridopyrazinediones are of Formula (I): (I), wherein R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.