KRISTINA VALERIE THOMAS
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD448304
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15122
Personal information
See more information about KRISTINA VALERIE THOMAS at radaris.comName
Address
Phone
411 Saint Vincent St, Philadelphia, PA 19111
8520 Verree Rd #A, Philadelphia, PA 19111
8520 Verree Rd, Philadelphia, PA 19111
2 School Ct, Avella, PA 15312
139 Wylie Ave, Washington, PA 15301
Professional information
See more information about KRISTINA VALERIE THOMAS at trustoria.com
Surfactant-Based Antimicrobial Solution For Inhalation
Surfactant-Based Antimicrobial Solution For Inhalation
US Patent:
2009005, Feb 26, 2009
Filed:
Aug 21, 2008
Appl. No.:
12/195544
Inventors:
Tim Corcoran - Pittsburgh PA, US
Amy Lise Marcinkowski - Syracuse NY, US
Joseph Pilewski - Pittsburgh PA, US
Kristina Thomas - Pittsburgh PA, US
Amy Lise Marcinkowski - Syracuse NY, US
Joseph Pilewski - Pittsburgh PA, US
Kristina Thomas - Pittsburgh PA, US
International Classification:
A61K 9/12, A61K 31/7036, A61K 31/546, A61K 31/427, A61K 38/12, A61K 31/7052, A61K 31/155, A61K 31/65, A61P 31/10, A61P 31/04, A61P 31/12, A61K 31/5377, A61K 31/407, A61K 31/44, A61K 31/496, A61K 31/351, A61K 31/7048
US Classification:
424 45, 514 40, 514203, 51421015, 514 10, 514 29, 514636, 514152, 5142368, 51421013, 514354, 51425411, 514459, 514 31
Abstract:
A surfactant can be added, safely and effectively, to a drug solution containing any antimicrobial agent, such as an antibiotic like tobramycin, that is suitable for administration to the lungs via inhalation. Thus, when an aerosolized drug solution includes surfactant, Marangoni flows cause the drug particles, once deposited in the lungs, to spread over a wider surface area, thereby ensuring greater antimicrobial efficacy. A solution that contains, for example, an antibiotic and tyloxapol or another surfactant providing a similar surface tension to the composition is optimally delivered by the functional combination of a breath-actuated nebulizer and a high-flow compressor.