Inventors:
Mark COLGIN - Castle Rock CO, US
Irving Boime - St. Louis MO, US
Janet Roser - Davis CA, US
Kory Niswender - Granbury TX, US
Assignee:
AspenBio Pharma Inc. - Castle Rock CO
International Classification:
A61K 38/24, C07K 14/575, C07H 21/04, C12N 15/63, C12N 5/10, A61P 15/00
US Classification:
514 12, 530399, 536 2351, 4353201, 435325
Abstract:
The present invention provides methods of producing biologically active recombinant eFSH analogs and methods of increasing reproduction in mammals, particularly equine, using recombinant eFSH analogs. Also provided are methods of producing biologically active single chain recombinant eFSH. The recombinant eFSH analogs of the present invention increase superovulation, follicular development, embryo development, and reproductive efficiency in horses, cattle and other ungulates.