KOICHI SHUN KUNITAKE
Osteopathic Medicine in Twntynine Plm, CA
License number
California 118976
Category
Osteopathic Medicine
Type
Emergency Medicine
Address
Address
2
1145 Sturgis Rd, Twntynine Plm, CA 92278
3773 Haines St APT 18, San Diego, CA 92109
3773 Haines St APT 18, San Diego, CA 92109
Phone
(760) 830-2722
(858) 245-2353
(858) 245-2353
Professional information
Dr. Koichi S Kunitake, San Diego CA - MD (Doctor of Medicine)
Specialties:
Emergency Medicine
Address:
13286 Glencliff Way, San Diego 92130
Certifications:
Emergency Medicine, 2010
Awards:
Healthgrades Honor Roll
Languages:
English
Urocortin-Iii And Uses Thereof
US Patent:
6812210, Nov 2, 2004
Filed:
Mar 15, 2002
Appl. No.:
10/099766
Inventors:
Jean E. River - La Jolla CA
Koichi S. Kunitake - San Diego CA
Kathy A. Lewis - San Diego CA
Marilyn H. Perrin - La Jolla CA
Jozsef Gulyas - Julian CA
Koichi S. Kunitake - San Diego CA
Kathy A. Lewis - San Diego CA
Marilyn H. Perrin - La Jolla CA
Jozsef Gulyas - Julian CA
Assignee:
Research Development Foundation - Carson City NV
International Classification:
A61K 3800
US Classification:
514 12
Abstract:
A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2 or. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.
Urocortin-Iii And Uses Thereof
US Patent:
8445425, May 21, 2013
Filed:
Dec 16, 2011
Appl. No.:
13/328821
Inventors:
Kathy A. Lewis - San Diego CA, US
Marilyn H. Perrin - La Jolla CA, US
Koichi S. Kunitake - San Diego CA, US
Jean E. Rivier - La Jolla CA, US
Jozsef Gulyas - Julian CA, US
Marilyn H. Perrin - La Jolla CA, US
Koichi S. Kunitake - San Diego CA, US
Jean E. Rivier - La Jolla CA, US
Jozsef Gulyas - Julian CA, US
Assignee:
Research Development Foundation - Carson City NV
International Classification:
C07K 14/00
US Classification:
514 1, 530300, 530350
Abstract:
A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.
Urocortin-Iii And Uses Thereof
US Patent:
6953838, Oct 11, 2005
Filed:
Feb 3, 2004
Appl. No.:
10/771224
Inventors:
Jean E. Rivier - La Jolla CA, US
Koichi S. Kunitake - San Diego CA, US
Kathy A. Lewis - San Diego CA, US
Marilyn H. Perrin - La Jolla CA, US
Jozsef Gulyas - Julian CA, US
Koichi S. Kunitake - San Diego CA, US
Kathy A. Lewis - San Diego CA, US
Marilyn H. Perrin - La Jolla CA, US
Jozsef Gulyas - Julian CA, US
Assignee:
Research Development Foundation - Carson City NV
International Classification:
A61K039/00, C07K014/47
US Classification:
530350, 530408, 4241851
Abstract:
A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.
Urocortin-Iii And Uses Thereof
US Patent:
2014000, Jan 2, 2014
Filed:
May 1, 2013
Appl. No.:
13/875117
Inventors:
Marilyn H. PERRIN - La Jolla CA, US
Koichi KUNITAKE - San Diego CA, US
Jean E. F. RIVIER - La Jolla CA, US
Jozsef GULYAS - Julian CA, US
Koichi KUNITAKE - San Diego CA, US
Jean E. F. RIVIER - La Jolla CA, US
Jozsef GULYAS - Julian CA, US
Assignee:
Research Development Foundation - Carson City NV
International Classification:
C07K 14/695
US Classification:
435348, 536 235, 4353201, 435325, 4352542
Abstract:
A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.
Urocortin-Iii And Uses Thereof
US Patent:
7459427, Dec 2, 2008
Filed:
Aug 29, 2005
Appl. No.:
11/214371
Inventors:
Kathy A. Lewis - San Diego CA, US
Marilyn H. Perrin - La Jolla CA, US
Koichi S. Kunitake - San Diego CA, US
Jean E. Rivier - La Jolla CA, US
Jozsef Gulyas - Julian CA, US
Marilyn H. Perrin - La Jolla CA, US
Koichi S. Kunitake - San Diego CA, US
Jean E. Rivier - La Jolla CA, US
Jozsef Gulyas - Julian CA, US
Assignee:
Research Development Foundation - Carson City NV
International Classification:
C07K 14/00
US Classification:
514 2, 530350
Abstract:
A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.
Urocortin-Iii And Uses Thereof
US Patent:
8084413, Dec 27, 2011
Filed:
Nov 6, 2008
Appl. No.:
12/266430
Inventors:
Kathy A. Lewis - San Diego CA, US
Marilyn H. Perrin - La Jolla CA, US
Koichi S. Kunitake - San Diego CA, US
Jean E. Rivier - La Jolla CA, US
Jozsef Gulyas - Julian CA, US
Marilyn H. Perrin - La Jolla CA, US
Koichi S. Kunitake - San Diego CA, US
Jean E. Rivier - La Jolla CA, US
Jozsef Gulyas - Julian CA, US
Assignee:
Research Development Foundation - Carson City NV
International Classification:
C07K 14/00
US Classification:
514 1, 530300, 530350
Abstract:
A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.