KLAUS D. HAGSPIEL, M.D.
Radiology in Charlottesville, VA

2002000, Jan 17, 2002

Mar 12, 2001

09/804369

Bastiaan Driehuys - Durham NC, US
Dennis Fujii - Downingtown PA, US
James Brookeman - Charlottesville VA, US
Klaus Hagspiel - Charlottesville VA, US

A61K049/06

424/009300

A method of screening for pulmonary embolism uses gaseous phase polarized Xe which is injected directly into the vasculature of a subject. The gaseous Xe can be delivered in a controlled manner such that the gas substantially dissolves into the vasculature proximate to the injection site. Alternatively, the gas can be injected such that it remains as a gas in the bloodstream for a period of time (such as about 8-29 seconds). The injectable formulation of polarized Xe gas is presented in small quantities of (preferably isotopically enriched) hyperpolarized Xe and can provide high-quality vasculature MRI images or NMR spectroscopic signals with clinically useful signal resolution or intensity. One method injects the polarized Xe as a gas into a vein and also directs another quantity of polarized gas into the subject via inhalation. In this embodiment, the perfusion uptake allows arterial signal information and the injection (venous side) allows venous signal information. The dual delivery is used to generate a combined introduction path with a more complete image signal of both the arterial and venous side of the pulmonary vasculature. In this NMR imaging method, the pulmonary embolism screening method can use the same NMR chest coil for the excitation and detection of the Xe signals. The direct injection of small quantities of gas at particular sites along the vasculature targets specific target regions to provide increased signal intensity NMR images. The disclosure also includes related methods directed to other diagnostic vasculature regions physiological and conditions. Associated delivery and dispensing systems and methods, containers, and quantitative formulations of the polarized gas are also described.

7560096, Jul 14, 2009

Jul 10, 2003

10/617326

Bastiaan Driehuys - Durham NC, US
Klaus D. Hagspiel - Charlottesville VA, US

Medi-Physics, Inc - Princeton NJ

A61B 5/055

424 93, 424 111, 424 165, 424 181, 424 91, 424 92

A method of screening for pulmonary embolism uses gaseous phase polarized Xe which is injected directly into the vasculature of a subject. The gaseous Xe can be delivered in a controlled manner such that the gas substantially dissolves into the vasculature proximate to the injection site. Alternatively, the gas can be injected such that it remains as a gas in the bloodstream for a period of time (such as about 8-29 seconds). The injectable formulation of polarized Xe gas is presented in small quantities of (preferably isotopically enriched) hyperpolarized Xe and can provide high-quality vasculature MRI images or NMR spectroscopic signals with clinically useful signal resolution or intensity. One method injects the polarized Xe as a gas into a vein and also directs another quantity of polarized gas into the subject via inhalation. In this embodiment, the perfusion uptake allows arterial signal information and the injection (venous side) allows venous signal information.