MS. KIMBERLY STEGMAIER, MD
Medical Practice at Binney St, Boston, MA
License number
Massachusetts 160019
Category
Medical Practice
Type
Pediatric Hematology-Oncology
Address
Address
44 Binney St, Boston, MA 02115
Phone
(617) 632-4985
(617) 632-4850 (Fax)
(617) 983-3943
(617) 632-4850 (Fax)
(617) 983-3943
Personal information
See more information about KIMBERLY STEGMAIER at radaris.comName
Address
Phone
28 Marshal St, Brookline, MA 02446
156 Saint Paul St, Brookline, MA 02446
28 Marshall St, Brookline, MA 02446
45 Saint Paul St, Brookline, MA 02446
49 Prince St, Jamaica Plain, MA 02130
Organization information
See more information about KIMBERLY STEGMAIER at bizstanding.comKimberly Stegmaier MD
450 Brookline Ave, Boston, MA 02215
Categories:
Physicians & Surgeons
Phone:
(617) 582-4300 (Phone)
Professional information
Dr. Kimberly Stegmaier, Framingham MA - MD (Doctor of Medicine)
Specialties:
Pediatric Hematology & Oncology
Address:
761 Worcester Rd, Framingham 01701
(508) 788-1700 (Phone)
(508) 788-1700 (Phone)
Certifications:
Pediatric Oncology & Pediatric Hematology, 2002, Pediatrics, 1999
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
761 Worcester Rd, Framingham 01701
Brigham and Women's Hospital
75 Francis St, Boston 02115
Massachusetts General Hospital
55 Fruit St, Boston 02114
North Shore Medical Center - Salem Hospital
81 Highland Ave, Salem 01970
Brigham and Women's Hospital
75 Francis St, Boston 02115
Massachusetts General Hospital
55 Fruit St, Boston 02114
North Shore Medical Center - Salem Hospital
81 Highland Ave, Salem 01970
Education:
Medical School
Harvard Medical School
Graduated: 1996
Children's Hospital Boston
Dana Farber Cancer Instit and Chldrn's Hospital
Harvard Medical School
Graduated: 1996
Children's Hospital Boston
Dana Farber Cancer Instit and Chldrn's Hospital
Kimberly Stegmaier, Boston MA
Specialties:
Pediatric Hematology-Oncology, Hematology & Oncology, Medical Oncology
Work:
Dana-Farber Cancer Institute
450 Brookline Ave, Boston, MA 02215 Dana-Farber Cancer Institute
44 Binney St, Boston, MA 02115 Children's Hospital
300 Longwood Ave, Boston, MA 02115
450 Brookline Ave, Boston, MA 02215 Dana-Farber Cancer Institute
44 Binney St, Boston, MA 02115 Children's Hospital
300 Longwood Ave, Boston, MA 02115
Education:
Harvard University(1996)
Celastrol, Gedunin, And Derivatives Thereof As Hsp90 Inhibitors
US Patent:
2011026, Oct 27, 2011
Filed:
Mar 30, 2007
Appl. No.:
12/294507
Inventors:
Todd R. Golub - Newton MA, US
Justin Lamb - Cambridge MA, US
Kimberly Stegmaier - Jamaica Plain MA, US
Justin Lamb - Cambridge MA, US
Kimberly Stegmaier - Jamaica Plain MA, US
Assignee:
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:
A61K 31/352, A61K 31/225, A61K 31/19, A61P 35/00, C07D 311/78, C07C 69/604, C07C 63/44, A61P 35/02, C12N 5/09, C07D 493/04
US Classification:
514453, 435375, 514548, 514569, 549275, 549277, 560194, 562405
Abstract:
Based on the discovery that celastrol and gedunin are Hsp90 inhibitors, the present invention provides novel inhibitors of Hsp90. and pharmaceutically acceptable salts, derivatives, and compositions thereof. The invention provides two classes of compounds. One class includes celastrol and its derivatives. The other class includes gedunin and its derivatives. The present invention further provides methods for treating disorders wherein Hsρ90 inhibition is desired (e.g., proliferative diseases, cancer, inflammatory diseases, fungal infections, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. Celastrol, gedunin, and derivatives thereof are particularly useful in the treatment of prostate cancer, breast cancer, ovarian cancer, lung cancer, and leukemia.