Inventors:
Vijai Kumar - Morris Plains NJ 07950
Kevin Scott McGuffy - Stanhope NJ 07874
International Classification:
A61K 914
US Classification:
424468, 424465, 424469, 424486, 424488, 424489, 5147723, 514770, 514777, 514781, 514866, 514965, 514951
Abstract:
An extended-release matrx formulation capable of being directly compressed into tablets comprising metformin hydrochloride blended with specific excipients. The excipients used in the formulation enhance the flow and compaction properties of the drug and insure that the formulation is directly compressible into a tablet containing about 100 mg to about 800 mg, preferably about 250 mg to about 750 mg, of metformin hydrochloride in unit dosage form. Each tablet produced by direct compression of the formulaton has the desired hardness and dissolution characteristics such that the drug is released in the body of the subject over an extended period of time.