KEVIN N SHETH, M.D.
Neurology in Baltimore, MD
License number
Maryland D69306
Category
Neurology
Type
Neurology
Address
Address
110 Floor, Baltimore, MD 21201
Phone
(443) 615-4729
Professional information
Dr. Kevin N Sheth, Baltimore MD - MD (Doctor of Medicine)
Specialties:
Vascular Neurology
Age:
45
Address:
University Maryland Medical Center NEU
16 S Eutaw St, Baltimore 21201
(410) 328-5660 (Phone)
Neurology Ambulatory Center
210 SOUTH Paca St, Baltimore 21201
(410) 328-4323 (Phone)
16 S Eutaw St, Baltimore 21201
(410) 328-5660 (Phone)
Neurology Ambulatory Center
210 SOUTH Paca St, Baltimore 21201
(410) 328-4323 (Phone)
Procedures:
EEG (Electroencephalogram), EMG (Electromyography)
Conditions:
Brain Injury, Cerebral Artery Thrombosis, Convulsions, Cranial Trauma, Dementia, Diabetic Polyneuropathy, Diplopia, Dystonia, Epilepsy, Essential Tremor, Gait Abnormality, Headache, Inflammatory and Toxic Neuropathy, Migraine, Peripheral Nerve Disorders, Sleep Apnea, Spinal Stenosis, Syncope, Transient Ischemic Attack (TIA), Tremor, Vertigo
Certifications:
Neurology, 2008, Vascular Neurology, 2009
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
University Maryland Medical Center NEU
16 S Eutaw St, Baltimore 21201
Neurology Ambulatory Center
210 SOUTH Paca St, Baltimore 21201
University of Maryland Medical Center
22 South Greene St, Baltimore 21201
16 S Eutaw St, Baltimore 21201
Neurology Ambulatory Center
210 SOUTH Paca St, Baltimore 21201
University of Maryland Medical Center
22 South Greene St, Baltimore 21201
Education:
Medical School
University Of Pennsylvania School Of Medicine
Graduated: 2003
Brigham and Women's Hospital
University Of Pennsylvania School Of Medicine
Graduated: 2003
Brigham and Women's Hospital
Mammalian Serine Racemase
US Patent:
6984484, Jan 10, 2006
Filed:
Jan 18, 2000
Appl. No.:
09/889609
Inventors:
Soloman H. Snyder - Baltimore MD, US
Herman Wolosker - Baltimore MD, US
Kevin Sheth - Baltimore MD, US
Takahashi Masaaki - Baltimore MD, US
Jean-Pierre Mothet - Baltimore MD, US
Roscoe Brady, Jr. - Baltimore MD, US
Christopher D. Ferris - Baltimore MD, US
Herman Wolosker - Baltimore MD, US
Kevin Sheth - Baltimore MD, US
Takahashi Masaaki - Baltimore MD, US
Jean-Pierre Mothet - Baltimore MD, US
Roscoe Brady, Jr. - Baltimore MD, US
Christopher D. Ferris - Baltimore MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
C12Q 1/25, C12N 9/90
US Classification:
435 4, 435233
Abstract:
High levels of D-serine occur in mammalian brain, where it appears to be an endogenous ligand of the “glycine site” of NMDA receptors. We have purified from rat brain a soluble enzyme that catalyzes the direct racemization of L-serine to D-serine. Purified serine racemase has a molecular weight of 37 kDa and requires pyridoxal 5′-phosphate for its activity. The enzyme is highly selective toward L-serine, failing to racemize any other amino acid tested. We have also identified polynucleotide sequences that encode mammalian, including human, serine racemase. Compounds that modulate the activity of mammalian serine racemase are useful for treating conditions and diseases that involve overstimulation of NMDA receptors, such as stroke and various neurodegenerative diseases.