KEVIN MCCARTHY
Broker in Haverhill, MA
License number
Massachusetts 70522
Issued Date
Sep 1, 1985
Expiration Date
Mar 14, 2004
Type
Salesperson
Address
Address
Haverhill, MA 01830
Personal information
See more information about KEVIN MCCARTHY at radaris.comName
Address
Phone
447 Kelley Blvd, N Attleboro, MA 02760
44 Bird Rd, Mansfield, MA 02048
43 Franklin St, Salem, MA 01970
43 Chestnut St #2, Waltham, MA 02453
46 Main St, Nantucket, MA 02554
Professional information
See more information about KEVIN MCCARTHY at trustoria.com
Temperature-Induced Polynucleotides And Uses Therefor
Temperature-Induced Polynucleotides And Uses Therefor
US Patent:
2010013, May 27, 2010
Filed:
Nov 10, 2009
Appl. No.:
12/615710
Inventors:
Kevin Michael MCCARTHY - Haverhill MA, US
Robin Allison Heller-Harrison - Andover MA, US
Mark William Leonard - Manchester NH, US
Timothy Shea Charlebois - Andover MA, US
Robin Allison Heller-Harrison - Andover MA, US
Mark William Leonard - Manchester NH, US
Timothy Shea Charlebois - Andover MA, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A01K 67/00, C07K 2/00, C12N 5/10, C07H 21/00, C07H 21/04, C12N 15/74
US Classification:
800 13, 530300, 536 231, 435358, 536 245, 536 235, 536 241, 4353201
Abstract:
The present invention is based on the discovery that the transcriptional activity of both hamster mammary tumor 7 (HMT-7) and hamster layilin genes are increased when Chinese Hamster Ovary (CHO) cells are cultured at temperatures lower than 37° C. The present invention provides novel genomic, cDNA, and protein sequences of HMT-7 and a novel genomic sequence for hamster layilin. Included in the genomic sequences are novel temperature-induced promoter sequences for each; two promoter sequences are provided for HMT-7 and one promoter sequence is provided for layilin. The invention additionally provides antisense and siRNA molecules to the nucleic acid molecules of HMT-7. The invention also provides genetically engineered expression vectors comprising the novel temperature-induced promoters of the invention, which are particularly useful as part of a mammalian temperature-inducible expression system. The invention also provides host cells and/or transgenic animals comprising the novel nucleic acid molecules of the invention. The invention further provides methods of using the polynucleotides of the invention, e.g., for temperature-induced transgene expression.
Methods For Identifying Cells Suitable For Large-Scale Production Of Recombinant Proteins
Methods For Identifying Cells Suitable For Large-Scale Production Of Recombinant Proteins
US Patent:
2011001, Jan 20, 2011
Filed:
Mar 12, 2009
Appl. No.:
12/921717
Inventors:
Kevin Michael McCarthy - Haverhill MA, US
Megan Jill Hone - Hudson NH, US
Robin Allison Heller-Harrison - Andover MA, US
Mark William Leonard - Manchester NH, US
Megan Jill Hone - Hudson NH, US
Robin Allison Heller-Harrison - Andover MA, US
Mark William Leonard - Manchester NH, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
C12Q 1/68, C12N 5/071
US Classification:
435 6, 435325
Abstract:
The present invention provides methods of identifying a clonal population of cells suitable for large-scale production of a protein of interest. The invention further provides methods for high-throughput screening for genetic rearrangements in the gene encoding the protein of interest, whereby the absence of a deletion in the gene encoding the protein of interest indicates that the cell is suitable for large-scale production of the protein of interest.