Kevin Matthew Flanigan
Physician in Salt Lake City, UT
License number
Utah 295773-1205
Issued Date
Aug 23, 1995
Expiration Date
Jan 31, 2010
Category
Physician
Type
Physician & Surgeon
Address
Address
Salt Lake City, UT
Personal information
See more information about Kevin Matthew Flanigan at radaris.comName
Address
Phone
131 J St, Salt Lake Cty, UT 84103
131 North, Salt Lake City, UT 84103
131 N St, Salt Lake City, UT 84103
829 4Th Ave, Salt Lake City, UT 84103
Professional information
Tissue Culture Assay For Measuring Drug Induced Translational Recoding At Premature Stop Codons And Frameshift Mutations
US Patent:
2003004, Mar 13, 2003
Filed:
Jul 31, 2002
Appl. No.:
10/210200
Inventors:
Michael Howard - Salt Lake City UT, US
Raymond Gesteland - Salt Lake City UT, US
John Atkins - Salt Lake City UT, US
Kevin Flanigan - Salt Lake City UT, US
Raymond Gesteland - Salt Lake City UT, US
John Atkins - Salt Lake City UT, US
Kevin Flanigan - Salt Lake City UT, US
Assignee:
University of Utah
International Classification:
C12Q001/68, C12Q001/66
US Classification:
435/006000, 435/008000
Abstract:
Assays for screening small-molecule compounds for their ability to induce translational readthrough of stop codons are disclosed. The assays utilize a dual enzymatic reporter plasmid system, wherein one reporter acts as an internal standard and the second reporter measures the translational recoding event induced by the small-molecules. The genetic sequence mutations of interest are placed on the plasmid between the two reporter genes and the plasmids are transfected into tissue culture cells. The cells are then grown in the presence of varying amounts of small-molecule compounds and the induction of translational readthrough is measured.
Rapid Direct Sequence Analysis Of Multi-Exon Genes
US Patent:
2006022, Oct 5, 2006
Filed:
Dec 17, 2003
Appl. No.:
10/539178
Inventors:
Kevin Flanigan - Salt Lake City UT, US
Robert Weiss - Salt Lake City UT, US
Diane Dunn - Salt Lake City UT, US
Andrew Niederhausern - Salt Lake City UT, US
Robert Weiss - Salt Lake City UT, US
Diane Dunn - Salt Lake City UT, US
Andrew Niederhausern - Salt Lake City UT, US
International Classification:
C12Q 1/68, C12P 19/34
US Classification:
435006000, 435091200
Abstract:
Disclosed is a Single Condition Amplification/Internal Primer (SCAIP) sequencing method which allows for the rapid, accurate, and economical analysis of any large multi-exon gene. The method can be used to detect genomic mutations in any large multi-exon gene including the dystrophin gene. In some forms, the method can rely on amplification of a large number of exons at a single set of PCR temperatures with a first set of amplification primers followed by sequencing without optimization of individual amplicon conditions, using a second, internal set of sequencing primers. The SCAIP method provides for the identification and analysis of specific individual genomic mutations such as deletions, point mutations, frameshifts, or combinations thereof, in gene complexes with multiple exons/introns spanning large genomic regions.