Inventors:
Christopher L. Parks - Boonton NJ, US
Kevin J. Wright - Brooklyn NY, US
Maoli Yuan - Brooklyn NY, US
Christy K. Jurgens - Rahway NJ, US
Xinsheng Zhang - Merrick NY, US
Arban Domi - Parsippany NJ, US
Simon Hoffenberg - Hartsdale NY, US
Maria J. Chiuchiolo - Brooklyn NY, US
Svetlana Rabinovich - Staten Island NY, US
Aaron J. Wilson - Brooklyn NY, US
Ivo C. Lorenz - Brooklyn NY, US
Assignee:
International AIDS Vaccine Initiative - New York NY
International Classification:
C12N 15/68
Abstract:
The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.