Inventors:
Brian D. Burkinshaw - Pflugerville TX, US
Steven I. Whitlock - Austin TX, US
Kevin Pauza - Tyler TX, US
Mark I. Richards - Leander TX, US
James B. Rogan - Austin TX, US
International Classification:
A61K 38/48, A61F 2/44, A61K 35/12, A61B 17/34, A61P 19/00, A61K 39/395, A61M 5/00, A61M 25/00
US Classification:
4241301, 604506, 604272, 604264, 60416401, 424 9464, 424 937, 424 9321
Abstract:
A method of treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, wherein the fibrinogen, the activating compound or both has been reconstituted with a solution containing at least one additive, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.