Inventors:
Laura Knoll - Madison WI, US
Lori Neal - Madison WI, US
Kevin O'Brien - Memphis TN, US
International Classification:
A61K 35/68, A61K 38/44, A61P 31/16, A61P 31/10, A61P 31/04, A61P 31/12, C12N 1/10, A61P 31/00
US Classification:
424 931, 4352581, 424780, 424 944
Abstract:
The invention provides a composition comprising an amount of a live attenuated or avirulent strain or a soluble extract thereof or a soluble extract of a wild-type strain effective to inhibit or prevent heterologous microbial pathogen infection or replication, or one or more symptoms or manifestations of the microbial pathogen infection or replication, and methods of making or using the compositions.