Inventors:
ABBOTT MOLECULAR INC. - Des Plaines IL, US
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN, US
Ekaterina Pestova - Glenview IL, US
Emily Barr Fricher - Rochester MN, US
Lewis Roberts - Rochester MN, US
Gregory Gores - Rochester MN, US
Kevin Halling - Rochester MN, US
Benjamin Kipp - Rochester MN, US
Assignee:
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN
ABBOTT MOLECULAR INC. - Des Plaines IL
International Classification:
C12Q 1/68
Abstract:
A method of detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract or inferring an increased risk thereof, comprising obtaining a sample of pancreatobiliary cells from a patient with a set of detectably labeled probes comprising a locus-specific probe for MCL1 (myeloid cell leukemia sequence 1), a locus-specific probe for EGFR (epidermal growth factor receptor), a locus-specific probe for MYC, and a locus-specific probe for P16 under hybridization conditions and determining the presence of chromosomal abnormalities; a set of probes comprising a locus-specific probe for MCL1, a locus-specific probe for EGFR, a locus-specific probe for MYC, and a locus-specific probe for P16; and a kit comprising the set of probes and instructions for detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract, or inferring an increased risk thereof, in a patient.