Inventors:
Richard Y. Liu - Lutz FL
Kenneth S. Zuckerman - Tampa FL
Assignee:
University of South Florida - Tampa FL
International Classification:
A61K 3808
US Classification:
514 14, 514 16, 530327, 530329, 435 78
Abstract:
There is provided a method of inhibiting TNF- from binding to TNF receptors by administering an effective amount of an inhibitory peptide. Also provided is a method of inhibiting TNF- functions by administering an effective amount of an inhibitory peptide. There also are provided peptides which have TNF- inhibitory properties. Also provided is a method of inhibiting TNF- binding to TNF receptors by administering an effective amount of peptides having the amino acid sequences shown in SEQ ID No. 1,2,3,4, wherein the peptides can be administered either singly or in combination.