Inventors:
Kenneth Kosik - Santa Barbara CA, US
International Classification:
A61K 48/00, C07H 21/02, C12N 5/08
US Classification:
514044000, 536023100, 435455000, 435368000
Abstract:
The present invention relates to siRNA molecules derived from BACE1 and BACE2 genes. Accordingly, provided herein are siRNA molecules comprising a nucleotide sequence consisting essentially of a BACE1 or BACE2 gene. Also provided are methods for reducing the level of BACE1 protein in a cell. Further provided are methods for preparing a pharmaceutical composition comprising an siRNA with a pharmaceutically acceptable carrier.