Inventors:
Kenneth Manzo - Shohola PA, US
Jay Sharma - Rancho Palos Verdes CA, US
International Classification:
A61K 35/74, A61P 3/00, C12N 15/74, C12N 1/21, A61K 9/19
US Classification:
424490, 4352529, 424 932, 435471
Abstract:
The present invention relates to genetically engineered bacteria that are able to colonize the mammalian intestine and actively produce mammalian lactase (lactose-phlorizin hydrolase or LPH). This lactose-digesting enzyme is stable and active under the conditions normally found in the mammalian small intestine. Experimental subjects colonized with the genetically engineered bacteria show improved ability to digest lactose in dairy foods.