Compounds Inhibiting Cox-2 And Inos Promoter Activities
US Patent:
6969532, Nov 29, 2005
Filed:
Jul 31, 2001
Appl. No.:
09/920121
Inventors:
Kenneth K. Wu - Houston TX, US
International Classification:
C12N005/00
US Classification:
424572, 424520, 435325, 435366, 435190, 514 1
Abstract:
A new chemical compound for treating human inflammatory diseases, tissue damage, stroke, septic shock and cancer. This chemical compound is produced from a process including the following steps: (a) washing human foreskin fibroblasts with a fresh DMEM medium then incubated in a fresh medium containing 2. 5%-10% fetal bovine serum for at least 8 hours to form a proliferating phase medium (PPM); (b) subjecting the proliferating phase medium to a 10-kDa ultrafiltration membrane to separate the proliferating phase medium into a 10 kDa fraction, which is retained by the 10-kDa ultrafiltration membrane; (c) Chromatographing the
Dr. Kenneth Q Wu, Chicago IL - MD (Doctor of Medicine)
Specialties:
Anesthesiology
Age:
42
Address:
1653 W Congress Pkwy, Chicago 60612 (312) 942-5000 (Phone), (312) 942-3145 (Fax) 6206 Bankside Dr, Houston 77096 RUSH UNIVERSITY MEDICAL CENTER 1750 W Harrison St SUITE 739, Chicago 60612 (312) 942-6504 (Phone), (312) 942-8858 (Fax)
Peroxisome Proliferator-Activator Receptor Δ (Pparδ) And The Development Of Preimplantation Embryos
US Patent:
8632452, Jan 21, 2014
Filed:
Oct 12, 2006
Appl. No.:
12/090060
Inventors:
Alfred W-S Wun - Houston TX, US Jennifer S. Goldsby - Houston TX, US Kenneth Wu - Houston TX, US
Assignee:
Board of Regents of the University of Texas System - Austin TX
International Classification:
A61B 17/43, C12N 5/06
US Classification:
600 35, 435375, 435404
Abstract:
Methods and compositions for enhancing development of a preimplantation mammalian embryo and for increasing the live birth potential of an in vitro fertilized mammalian embryo are disclosed. An in vitro method of activating the peroxisome proliferator activated receptor δ (PPARδ) in a preimplantation mammalian embryo comprises culturing an embryo in an embryo culture medium, and upon or after commencement of expression of PPARδ in the cells of the embryo, activating the PPARδ by adding an amount of a PPARδ ligand to said medium effective to bind to PPARδ to deter apoptosis in the cells of the cultured embryo and/or increase proliferation of the cells of the cultured embryo.
The present invention discloses vectors comprising a cyclooxygenase sequence, a prostaglandin synthase sequence or both. The invention further discloses methods of making such vectors, and compositions comprising such vectors. Methods for treating a patient afflicted with a vascular disorder by use of said vectors and compositions are also disclosed.