KENNETH J KLEIN
Engineers in Newark, DE

6648609, Nov 18, 2003

Apr 5, 2002

10/117984

Terry A. Berger - Newark DE
Kimber D. Fogelman - Hockessin DE
Kenneth Klein - Newark DE
Mark Nickerson - Landenburg PA

Berger Instruments, Inc. - Newark DE

F04B 4908

417297, 417292, 417248, 137613, 1376142, 137512, 251118, 2101982, 73 2342, 73 6156

The invention is a device and method in a high-pressure chromatography system, such as a supercritical fluid chromatography (SFC) system, that uses a pump as a pressure source for precision pumping of a compressible fluid. The preferred exemplary embodiment comprises a pressure regulation assembly installed downstream from a compressible fluid pump but prior to combining the compressible flow with a relatively incompressible modifier flow stream. The present invention allows the replacement of an high-grade SFC pump in the compressible fluid flow stream with an inexpensive and imprecise pump. The imprecise pump becomes capable of moving the compressible fluid flow stream in a precise flow rate and pattern. The assembly dampens the damaging effects of an imprecise pump, such as large pressure oscillations caused by flow ripples and noisy pressure signals that do not meet precise SFC pumping requirements.

6652753, Nov 25, 2003

Feb 4, 2002

10/067011

Terry A. Berger - Newark DE
Kimber D. Fogelman - Hockessin DE
L. Thompson Staats - Lincoln University PA
Mark Nickerson - Landenberg PA
Paul Bente - Landenberg PA
Kenneth J. Klein - Newark DE

Berger Instruments, Inc. - Newark DE

C02F 144

210634

A fractionated sample collection process and device having at least one pressurized chamber used to gather and store liquid samples generated from a flow stream containing a mixture of highly compressed gas, compressible liquid, or supercritical fluid and a relatively incompressible liquid. A bank of multiple collection chambers is secured together in a frame to form a cassette unit. Each collection chamber may house a replaceable liner such as a test tube vial, to hold a fractionated liquid phase sample. After filling with sample, a collection chamber is returned to a clean state and ready for refilling with a new sample by manually or automatically replacing the liner.

6656354, Dec 2, 2003

Feb 4, 2002

10/066955

Terry A. Berger - Newark DE
Kimber D. Fogelman - Hockessin DE
Mark Nickerson - Landenberg PA
Kenneth J. Klein - Newark DE

Berger Instruments, Inc. - Newark DE

B01D 1508

2101982, 210511, 210635, 210656, 210659

A fractionated sample collection process and device having at least one pressurized chamber used to gather and store liquid samples generated from a flow stream containing a mixture of highly compressed gas, compressible liquid, or supercritical fluid and a relatively incompressible liquid. A bank of multiple collection chambers is secured together in a frame to form a cassette unit. Each collection chamber may house a replaceable liner such as a test tube vial, to hold a fractionated liquid phase sample. After filling with sample, a collection chamber is returned to a clean state and ready for refilling with a new sample by manually or automatically replacing the liner.

6685828, Feb 3, 2004

Apr 9, 2002

10/119529

Terry A. Berger - Newark DE
Kimber D. Fogelman - Hockessin DE
Kenneth Klein - Newark DE
Mark Nickerson - Landenburg PA

Berger Instruments, Inc. - Newark DE

B01D 1508

2101982, 210656, 210659

A system for collection of liquid phase sample fractions from a supercritical fluid chromatography system is disclosed. The system has different ways of gathering the liquid phase into a collection chamber and provides for automated removal of liquid phase from a collection chamber into separate collection container. A separate pressure scheme is invoked upon the collection chambers to move liquid phase out of a chamber and into the separate collection container. In addition, the invention provides a renewal system for the collection chambers where each chamber returns to an uncontaminated stated by washing with a cleaning solution after removal of collected liquid phase. Spent cleaner from a chamber is purged using the pressure system into a waste stream for disposal.

6632353, Oct 14, 2003

Mar 29, 2002

10/113599

Terry A. Berger - Newark DE
Kimber D. Fogelman - Hockessin DE
Mark Nickerson - Landenburg PA
Kenneth Klein - Newark DE

Berger Instruments, Inc. - Newark DE

B01D 1508

2101982, 210656, 210659

A process and device for chromatography, such as preparative and analytical supercritical fluid chromatography, or supercritical fluid extraction for a liquid phase SFC collection system that separates and retains eluted components from sample injections. The process efficiently separates liquid and gas phases in the flow stream upstream of a collection vessel and without additional pressure schemes or solvent extractions imposed on the flowstream. Sample fractions are collected from sample component concentration peaks based upon the chromatographic elution of the sample components. Samples are repeatedly the injected into the mobile phase flow stream and collected into large volume collection containers, thereby allowing longer unattended run times and cost-efficient sample purification and recovery.

2004009, May 20, 2004

Nov 13, 2003

10/705940

Kenneth Klein - Newark DE, US
Kimber Fogelman - Hockessin DE, US
Vincent Worley - Wilmington DE, US
Terry Berger - Englewood FL, US

G01N033/558, C02F001/28, B01D015/08

436/514000, 210/656000

The invention relates to a system for sample fi-action collection in chromatography, and more specifically for using an extended vessel assembly that increases the total collectible volume of a liquid sample fraction in a single collection vessel in an automated system for collection, purification, and storage of purified sample fractions. The system uses an extended vessel assembly to provide collection of substantially large volumes of liquid fractions from chromatography system, such as a preparatory scale supercritical fluid chromatography (Prep Scale SFC) or preparatory scale liquid chromatography (Prep Scale LC), into a single collection vessel. The invention improves productivity while reducing the need for sample transfer between vessels and reducing the risk of human error. The collected liquid solvent is removed after purification using one of several types of evaporation devices or techniques, such as evaporation at moderate temperature under a vacuum with liquid agitation. Collection vessels are labeled and grouped into labeled racks for tracking, efficient movement between system modules, and storage.

7048517, May 23, 2006

Jun 18, 2003

10/464333

Terry A. Berger - Newark DE, US
Kimber D. Fogelman - Hockessin DE, US
Kenneth Klein - Newark DE, US
Mark Nickerson - Landenburg PA, US

Mettler-Toledo AutoChem, Inc. - Millersville MD

F04B 49/03

417300, 417 53, 417286, 417287, 73 2342, 73 6156, 73 2341

The invention is a device and method in a high-pressure chromatography system, such as a supercritical fluid chromatography (SFC) system, that uses a pump as a pressure source for precision pumping of a compressible fluid. The preferred exemplary embodiment comprises a pressure regulation assembly installed downstream from a compressible fluid pump but prior to combining the compressible flow with a relatively incompressible modifier flow stream. The present invention allows the replacement of an high-grade SFC pump in the compressible fluid flow stream with an inexpensive and imprecise pump. The imprecise pump becomes capable of moving the compressible fluid flow stream in a precise flow rate and pattern. The assembly dampens the damaging effects of an imprecise pump, such as large pressure oscillations caused by flow ripples and noisy pressure signals that do not meet precise SFC pumping requirements.

2004009, May 20, 2004

Nov 13, 2003

10/705907

Terry Berger - Englewood FL, US
Kenneth Klein - Newark DE, US
Kimber Fogelman - Hockessin DE, US
Vincent Worley - Wilmington DE, US

G01N030/80

073/061550

A mobile phase collection device for increasing the total collectible volume of a liquid fraction that is collected in supercritical fluid chromatography or liquid chromatography includes a collection vessel assembly that is suitable for increasing the total collectable volume of a liquid phase fraction while using a relatively smaller collection vessel. A vessel extender is attached to an attachment end of a relatively smaller collection vessel, resulting in the ability to increase the total volumetric size of a collection vessel. The extended vessel assembly can be used throughout an entire purification and dry down process.