Inventors:
Alan R. Giles - Kingston, CA
Kenneth G. Mann - Rochester MN
Assignee:
Queen's University at Kingston - Kingston
International Classification:
A61K 3514
Abstract:
A composition of matter for controlling Hemophilia A (Antihemophilic Factor (F. VIII:C) deficiency) in mammals is described. Factor VIII:C deficiency in the mammal is bypassed by infusion of a synergistic mixture of a phospholipid and Factor Xa so that the cascade process of blood clotting may continue. The proportions of phospholipid and Factor Xa in the mixture are critical as too little Xa has no effect while too much is toxic (thrombogenic).