Inventors:
Gary H. Posner - Baltimore MD
Qiang Wang - Newark CA
Kenneth R. Crawford - Baltimore MD
Gyoonhee Han - Nara, JP
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
C07C40100
Abstract:
Novel sulfur-containing analogs of 1,25-dihydroxy vitamin D are provided. These analogs are synthesized in a convergent manner by joining A-ring and C,D ring fragments. Each analog with 1,3-substituent stereochemistry shows a pharmacologically desirable combination of high antiproliferative and high transcriptional activities in vitro and also low calcemic activity in vivo.