Inventors:
Malaya Chatterjee - Fort Wright KY, US
Kenneth A. Foon - Pittsburgh PA, US
Sunil K. Chatterjee - Fort Wright KY, US
Assignee:
University of Kentucky Research Foundation - Lexington KY
International Classification:
C07H 21/04
US Classification:
536 2353, 4241331, 514 12
Abstract:
The present invention provides a monoclonal anti-Idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 induces an immunological response to HMFG in mice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 11D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment of HMFG—associated tumors.