KENNETH ALAN FOON
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD421416
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15211
Professional information
Kenneth Foon, Pittsburgh PA
Work:
Oncology Hematology Assn
5115 Centre Ave, Pittsburgh, PA 15232 Oncology Hematology Associates
400 Oxford Dr, Monroeville, PA 15146
5115 Centre Ave, Pittsburgh, PA 15232 Oncology Hematology Associates
400 Oxford Dr, Monroeville, PA 15146
Murine Monoclonal Anti-Idiotype Antibody 11D10 And Methods Of Use Thereof
US Patent:
7399849, Jul 15, 2008
Filed:
May 10, 2005
Appl. No.:
11/126798
Inventors:
Malaya Chatterjee - Fort Wright KY, US
Kenneth A. Foon - Pittsburgh PA, US
Sunil K. Chatterjee - Fort Wright KY, US
Kenneth A. Foon - Pittsburgh PA, US
Sunil K. Chatterjee - Fort Wright KY, US
Assignee:
University of Kentucky Research Foundation - Lexington KY
International Classification:
C07H 21/04
US Classification:
536 2353, 4241331, 514 12
Abstract:
The present invention provides a monoclonal anti-Idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 induces an immunological response to HMFG in mice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 11D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment of HMFG—associated tumors.