Inventors:
Kelly Reed Clark - Columbus OH, US
Assignee:
NATIONWIDE CHILDREN'S HOSPITAL - Columbus OH
International Classification:
A61K 39/00, C12N 15/11, C12N 5/06, A61P 31/00, C12P 21/04
US Classification:
4241991, 536 2372, 435325, 435 696
Abstract:
The present invention relates generally to the use of recombinant adeno-associated viruses (rAAV) for gene delivery and more specifically to the use of rAAV to deliver antibody genes to target cells in mammals. Administration of rAAV encoding antibodies that neutralize the HIV-1 virus is exemplified.