KEITH RICHARD CROMACK
Pilots at Lions Head Ct, Wildwood, MO
License number
Missouri A5037337
Issued Date
Dec 2015
Expiration Date
Dec 2017
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
2 Lions Head Ct, Wildwood, MO 63005
Professional information
Delivery Of Highly Lipophilic Agents Via Medical Devices
US Patent:
2009021, Aug 27, 2009
Filed:
Mar 22, 2006
Appl. No.:
11/886815
Inventors:
Keith R. Cromack - Chesterfield MO, US
John L. Toner - Libertyville IL, US
Sandra E. Burke - Libertyville IL, US
Richard W. Krasula - Libertyville IL, US
Lewis B. Schwartz - Lake Forest IL, US
John L. Toner - Libertyville IL, US
Sandra E. Burke - Libertyville IL, US
Richard W. Krasula - Libertyville IL, US
Lewis B. Schwartz - Lake Forest IL, US
International Classification:
A61F 2/82, A61K 31/436, A61K 31/7088, A61K 39/395, A61K 38/00, A61K 31/727, A61K 31/352, A61K 38/14, A61K 31/405, A61K 31/565, A61K 31/568, A61K 31/337, A61K 31/519, A61K 38/13, A61K 31/4745, A61K 31/573
US Classification:
623 142, 514291, 514 44 A, 514 44 R, 4241411, 514 2, 514 56, 514455, 514 8, 514420, 514182, 514178, 514449, 514249, 514 11, 514283, 5142621, 514180
Abstract:
An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.
Compositions And Methods Of Administering Rapamycin Analogs With Paclitaxel Using Medical Devices
US Patent:
2009016, Jun 25, 2009
Filed:
Oct 12, 2006
Appl. No.:
12/090253
Inventors:
Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Chesterfield MO, US
Matthew Mack - Chicago IL, US
John L. Toner - Libertyville IL, US
Keith R. Cromack - Chesterfield MO, US
Matthew Mack - Chicago IL, US
John L. Toner - Libertyville IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 9/00, A61K 31/337, A61K 31/395, A61K 31/56, A61P 7/02
US Classification:
424423, 514449, 514291, 514171
Abstract:
Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
Multiple Drug Delivery From A Balloon And A Prosthesis
US Patent:
8501213, Aug 6, 2013
Filed:
Sep 14, 2012
Appl. No.:
13/617628
Inventors:
John L. Toner - Libertyville IL, US
Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Chesterfield MO, US
Randolf von Oepen - Los Altos Hills CA, US
Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Chesterfield MO, US
Randolf von Oepen - Los Altos Hills CA, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61F 13/00
US Classification:
424422, 604509, 427 21
Abstract:
Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
Coatings Including Dexamethasone Derivatives And Analogs And Olimus Drugs
US Patent:
8092822, Jan 10, 2012
Filed:
Sep 29, 2008
Appl. No.:
12/240917
Inventors:
Stephen D. Pacetti - San Jose CA, US
John L. Toner - Libertyville IL, US
Keith R. Cromack - Chesterfield MO, US
John L. Toner - Libertyville IL, US
Keith R. Cromack - Chesterfield MO, US
Assignee:
Abbott Cardiovascular Systems Inc. - Santa Clara CA
International Classification:
A61F 2/00
US Classification:
424423
Abstract:
The present invention encompasses a coating on the surface of a substrate and the coated substrates. The coating includes a polymer, an olimus drug (sirolimus, everolimus, zotarolimus, etc. ), and a dexamethasone derivative. The polymer may be a hydrophobic polymer, preferably a fluoropolymer, and more preferably a fluoropolymer with at least 25% vinylidene fluoride by weight.
Multiple Drug Delivery From A Balloon And A Prosthesis
US Patent:
8431145, Apr 30, 2013
Filed:
Feb 13, 2009
Appl. No.:
12/371422
Inventors:
John L. Toner - Libertyville IL, US
Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Chesterfield MO, US
Randolf von Oepen - Los Altos Hills CA, US
Sandra E. Burke - Libertyville IL, US
Keith R. Cromack - Chesterfield MO, US
Randolf von Oepen - Los Altos Hills CA, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61F 13/00
US Classification:
424422, 604509, 427 21
Abstract:
Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
Coating On A Balloon Device
US Patent:
2011013, Jun 9, 2011
Filed:
Jan 27, 2011
Appl. No.:
13/015377
Inventors:
Syed F. A. Hossainy - Hayward CA, US
O. Mikael Trollsas - San Jose CA, US
Keith R. Cromack - Chesterfield MO, US
Stephen D. Pacetti - San Jose CA, US
O. Mikael Trollsas - San Jose CA, US
Keith R. Cromack - Chesterfield MO, US
Stephen D. Pacetti - San Jose CA, US
Assignee:
ABBOTT CARDIOVASCULAR SYSTEMS INC. - Santa Clara CA
International Classification:
A61M 25/10, A61F 2/00, A61K 47/30
US Classification:
604 9601, 424423, 5147723
Abstract:
The present invention provides a hygroscopic coating on a balloon for an implantable device and methods of making and using the same.