Keith Reemtsma
Physician in New York, NY

4563485, Jan 7, 1986

Apr 30, 1984

6/605792

Charles L. Fox - Ft. Lauderdale FL
Shanta Modak - River Edge NJ
Keith Reemtsma - New York NY

The Trustees of Columbia University in the City of New York - New York NY

A61K 31625

523113

Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as nalidixic acid derivatives or metal salts of nalidixic acid derivatives. In particular illustrative embodiments, silver norfloxacin and silver pefloxacin, are complexed with natural or synthetic polymeric materials such as silk, polyester (e. g. , Dacron), polyurethane, polytetrafluoroethylene, or silicone-based material, to provide long-term prevention of infections which may otherwise result during or after surgery or implantation of a device.

4581028, Apr 8, 1986

Apr 30, 1984

6/605793

Charles L. Fox - Ft. Lauderdale FL
Shanta Modak - River Edge NJ
Keith Reemtsma - New York NY

The Trustees of Columbia University in the City of New York - New York NY

A61F 224, A61F 228, A61F 230, A61K 31625

623 2

Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as metal salts of sulfonamides and other antimicrobials or antibacterials, such as piperacillin. In particular illustrative embodiments, silver sulfadiazine is complexed by novel techniques with natural or synthetic polymeric materials such as silk, polyester (e. g. , Dacron), polyurethane, polytetrafluoroethylene, or silicone-based material, to provide long-term prevention of infections which may otherwise result during, or after, surgery or implantation of a device.

4861704, Aug 29, 1989

Oct 8, 1986

6/918282

Keith Reemtsma - New York NY
Mark A. Hardy - Scarsdale NY
Henry T. Lau - New York NY

The Trustees of Columbia University in the City of New York - New York NY

A01N 102, C12N 1300

435 1

A patient's acceptance of a transplanted organ or tissue from a donor may be enhanced by irradiating donor-specific blood with ultraviolet-B radiation at a dosage of less than 1000 J/M. sup. 2 so as to render the blood capable of inducing donor-specific immunological unresponsiveness in the patient, transfusing the irradiated, donor-specific blood into the patient prior to transplanting the organ or tissue into the patient to enhance subsequent acceptance of the organ or tissue by the patient, and thereafter transplanting the organ or tissue into the subject. A patient's acceptance of transplanted organs and tissues can also be enhanced by removing the organ or tissue from the donor and irradiating the organ or tissue to be transplanted with ultraviolet-B radiation at a dosage of less than 1000 J/m. sup. 2 so as to enhance acceptance of the transplanted organ or tissue and then transplanting the irradiated organ or tissue into patient.

4946438, Aug 7, 1990

Jun 12, 1989

7/365013

Keith Reemtsma - New York NY
Mark A. Hardy - Scarsdale NY
Henry T. Lau - New York NY

The Trustees of Columbia University in the City of New York - New York NY

A01N 102, C12N 1300

604 53

A patient's acceptance of transplanted organs and tissues may be enhanced by treating donor specific blood with a suitable dose of ultraviolet radiation for an appropriate period of time, transfusing the irradiated blood into the patient during a suitable pretransplantation time period and then transplanting the organ or tissue into the subject. Acceptance of transplanted organs and tissues can also be enhanced by treating the organs or tissues to be transplanted with a suitable dose of ultraviolet radiation for an appropriate period of time and then transplanting the organ or tissue. Suitably irradiated donor specific blood, organs and tissues are preferred for use in transplantation.

5227298, Jul 13, 1993

Aug 17, 1990

7/568821

Collin J. Weber - Leonia NJ
Janet E. Norton - Scranton PA
Keith Reemtsma - New York NY

The Trustees of Columbia University in the City of New York - New York NY

C12N 1110, C12N 1104

435178

The subject invention provides a method of encapsulating viable tissue or cells within a double walled bead, the double-walled bean produced as a result of the method, as well as a method of pretreating the tissue or cells with an immunosuppressant such as UV-B irradiation prior to their encapsulation.