KEITH LEONARD MARCH
Pilots at John Paul Way, Carmel, IN
License number
Indiana A2380239
Issued Date
Jan 2015
Expiration Date
Jan 2017
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
14558 John Paul Way, Carmel, IN 46032
Professional information
Therapeutic And Diagnostic Agent Delivery
US Patent:
5997525, Dec 7, 1999
Filed:
Jun 29, 1998
Appl. No.:
9/107079
Inventors:
Keith L. March - Carmel IN
Michael Aita - Sunnyvale CA
Randy Kesten - Mountain View CA
Craig Smith - Bronxville NY
Michael Aita - Sunnyvale CA
Randy Kesten - Mountain View CA
Craig Smith - Bronxville NY
Assignee:
Cardiogenesis Corporation - Sunnyvale CA
International Classification:
A61M 3100
US Classification:
604508
Abstract:
A system for treating a patient's heart which comprises a means to form channels in the heart wall and a means to deliver a therapeutic or diagnostic agent into the channels. Additionally, the system may comprise a means to retain the agent within the channels for a useful period of time. The system may be configured to be introduced percutaneously or intraoperatively. The system generally comprises an elongated, flexible lasing transmission means having a laser radiation emitting means and an delivery lumen opening at the distal end. Practice of the invention comprises forming channels in the heart wall and delivering a therapeutic or diagnostic agent into the channel. Gene therapy agents of this invention comprise vectors for transferring genetic information to the heart tissue in vivo or harvested cells which have been genetically engineered in vitro. Additionally, the invention may comprise retaining the agent within the channels, for example, by incorporating the agent in a viscous carrier.
Therapeutic And Diagnostic Agent Delivery
US Patent:
5840059, Nov 24, 1998
Filed:
Jun 7, 1995
Appl. No.:
8/483512
Inventors:
Keith L. March - Carmel IN
Michael Aita - Sunnyvale CA
Randy Kesten - Mountain View CA
Craig Smith - Bronxville NY
Michael Aita - Sunnyvale CA
Randy Kesten - Mountain View CA
Craig Smith - Bronxville NY
Assignee:
CardioGenesis Corporation - Santa Clara CA
Indiana University Foundation - Bloomington IN
Columbia University - New York NY
Indiana University Foundation - Bloomington IN
Columbia University - New York NY
International Classification:
A61M 3100
US Classification:
604 53
Abstract:
A system for treating a patient's heart which comprises a means to form channels in the heart wall and a means to deliver a therapeutic or diagnostic agent into the channels. Additionally, the system may comprise a way to retain the agent within the channels for a useful period of time. The system may be configured to be introduced percutaneously or intraoperatively. The system generally comprises an elongated, flexible lasing transmission catheter that emits laser radiation and has delivery lumen opening at the distal end. Practice of the invention comprises forming channels in the heart wall and delivering a therapeutic or diagnostic agent into the channel. Gene therapy agents of this invention comprise vectors for transferring genetic information to the heart tissue in vivo or harvested cells which have been genetically engineered in vitro. Additionally, the invention may comprise retaining the agent within the channels, for example, by incorporating the agent in a viscous carrier.
Apparatus And Method For Positive Closure Of An Internal Tissue Membrane Opening
US Patent:
6348059, Feb 19, 2002
Filed:
Apr 20, 2000
Appl. No.:
09/553267
Inventors:
David Hathaway - Indianapolis IN
Brian Patton - Thorntown IN
Keith March - Carmel IN
Brian Patton - Thorntown IN
Keith March - Carmel IN
Assignee:
Advanced Research Technology Institute, Inc. - Bloomington IN
International Classification:
A61B 1704
US Classification:
606144, 606148, 128898
Abstract:
The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patients skin is also disclosed.
Methods For Inducing Vascular Remodeling And Related Methods For Treating Diseased Vascular Structures
US Patent:
2003021, Nov 20, 2003
Filed:
Mar 17, 2003
Appl. No.:
10/388592
Inventors:
Keith March - Carmel IN, US
Richard Popp - Los Altos Hills CA, US
Peter Fitzgerald - Portola Valley CA, US
Patrick Cahalan - Nashua NH, US
Daniel Burkhoff - Tenafly NJ, US
Laurence Roth - Windham NH, US
Nancy Briefs - Nashua NH, US
William Santamore - Medford NJ, US
Robert Swain - Bedford NH, US
Peter Boekstegers - Diessend A DE, US
Vincent Pompili - Chagrin Falls OH, US
Richard Popp - Los Altos Hills CA, US
Peter Fitzgerald - Portola Valley CA, US
Patrick Cahalan - Nashua NH, US
Daniel Burkhoff - Tenafly NJ, US
Laurence Roth - Windham NH, US
Nancy Briefs - Nashua NH, US
William Santamore - Medford NJ, US
Robert Swain - Bedford NH, US
Peter Boekstegers - Diessend A DE, US
Vincent Pompili - Chagrin Falls OH, US
International Classification:
A61F002/04
US Classification:
604/008000, 623/904000
Abstract:
A method for inducing vascular remodeling and related methods for treating patients having diseased vasculature. The method of inducing remodeling of the vascular system includes altering the blood flow dynamics in portions of the vascular system via mechanical mechanisms. Remodeling of certain coronary vasculature may be induced by creating a passage in a heart wall between a heart chamber and a blood vessel so as to permit blood flow communication, for example, direct blood flow communication, between the chamber and the vessel. A method of inducing vascular remodeling may include providing a blood flow passage between a heart chamber and the coronary vessel, or other flow dynamics altering structure, such that enlargement of at least a portion of the coronary vessel occurs.
Method And System For Modulation Of Oscillating Signals To Enhance Biologic Effects
US Patent:
2002005, May 2, 2002
Filed:
Nov 1, 2001
Appl. No.:
09/999051
Inventors:
Keith March - Carmel IN, US
International Classification:
A61N001/36
US Classification:
607/050000
Abstract:
A system and method for increasing the efficacy of stimulation signal therapy applied to selected tissue at a treatment site is disclosed. The method includes determining a stimulation signal capable of effecting desired results on the selected tissue and selectively modulating the stimulation signal such that the desired effect is achieved at the treatment site. The system includes a signal generator capable of generating a stimulation signal configured to produce a desired biologic effect on selected tissue at the treatment site, a modulator configured to selectively modulate the stimulation signal such that the stimulation signal correlates with at least one characteristic of the selected tissue and an emitter configured to apply the stimulation signal to the selected tissue.
Apparatus And Method For Positive Closure Of An Internal Tissue Membrane Opening
US Patent:
6132440, Oct 17, 2000
Filed:
Sep 22, 1998
Appl. No.:
9/158446
Inventors:
David Hathaway - Indianapolis IN
Brian Patton - Thorntown IN
Keith March - Carmel IN
Brian Patton - Thorntown IN
Keith March - Carmel IN
Assignee:
Advanced Research & Technology Institute - Bloomington IN
International Classification:
A61B 1704
US Classification:
606144
Abstract:
The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane. The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.
Adipose Stromal Stem Cells For Tissue And Vascular Modification
US Patent:
2012026, Oct 25, 2012
Filed:
Oct 21, 2011
Appl. No.:
13/279222
Inventors:
Keith L. March - Carmel IN, US
Jalees Rehman - Zionsville IN, US
Jalees Rehman - Zionsville IN, US
International Classification:
A61K 35/12, A61P 9/00
US Classification:
424 937
Abstract:
Methods are provided for promoting angiogenesis in a mammal, such methods including the administration of therapeutic quantity of adipose-derived stromal cells to a mammal such that therapeutic angiogenesis occurs.
Use Of Polyols For Improving The Introduction Of Genetic Material Into Cells
US Patent:
5552309, Sep 3, 1996
Filed:
Sep 30, 1994
Appl. No.:
8/315974
Inventors:
Keith L. March - Carmel IN
Assignee:
Indiana University Foundation - Bloomington IN
International Classification:
A01N 6300, C12N 500, C12N 1500
US Classification:
4351723
Abstract:
A process for introducing an expression vehicle (e. g. , plasmids, retroviral vectors, adenoviral vectors) into cells, which comprises contacting the cells with the expression vehicle and a polyol. The polyol may be a polyoxalkylene block copolymer, such as a polyoxypropylene-polyoxyethylene block copolymer. The use of the polyol provides for greater efficiency of transduction of the expression vehicle.
Adipose Tissue-Derived Stromal Cells And Methods Of Isolating And Using The Same
US Patent:
2012012, May 24, 2012
Filed:
Feb 1, 2012
Appl. No.:
13/363399
Inventors:
Keith L. March - Carmel IN, US
Jalees Rehman - Zionsville IN, US
Jalees Rehman - Zionsville IN, US
International Classification:
C12N 5/077, C12N 5/10
US Classification:
435325
Abstract:
Adipose tissue-derived stromal cells and methods of isolating and using the same. In at least one embodiment of isolated adipose tissue-derived stromal cells of the present disclosure, the cells are isolated by performing adipose tissue resection or suction on a mammalian patient, dissecting tissue obtained from said tissue resection or suction and dissociating said tissue into a cell suspension, removing adipocytes from the cell suspension, culturing the adipocyte-depleted cell suspension in EGM-2-MV media, and isolating adipose tissue-derived stromal cells secreting vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and granulocyte-colony stimulating factor (G-CSF).
Method For Preventing Restenosis Following Reconfiguration Of Body Vessels
US Patent:
5116864, May 26, 1992
Filed:
Apr 9, 1991
Appl. No.:
7/682627
Inventors:
Keith L. March - Carmel IN
David R. Hathaway - Indianapolis IN
Robert L. Wilensky - Indianapolis IN
Brian L. Patton - Thorntown IN
David R. Hathaway - Indianapolis IN
Robert L. Wilensky - Indianapolis IN
Brian L. Patton - Thorntown IN
Assignee:
Indiana University Foundation - Bloomington IN
International Classification:
A61K 3135
US Classification:
514455
Abstract:
Restenosis following vascular recanalization is prevented by administering a photoactivatable psoralen and, in conjunction with recanalization, delivering ultraviolet radiation to the region of said recanalization.