KAZURO L FUJIMOTO
Medical Practice in Pittsburgh, PA

2008009, Apr 24, 2008

Oct 10, 2007

11/869774

Jianjun Guan - Pittsburgh PA, US
William Wagner - Wexford PA, US
Kazuro Fujimoto - Pittsburgh PA, US

A61K 47/48, A61K 47/34, C08G 63/46, C12N 5/02

514772300, 435404000, 525190000, 525054100

Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room temperature and 37° C. so that they are liquid at room temperature and gelled at 37° C. which facilitates their use in humans, for example for wound treatment and as a cellular growth matrix or niche. The copolymer comprises numerous ester linkages in its backbone so that the copolymers are erodeable in situ. Degradation products of the polymer are soluble and non-toxic. The copolymer is amine-reactive so that it can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymer.

2008010, May 8, 2008

Aug 10, 2007

11/837235

William Wagner - Wexford PA, US
John Stankus - Campbell CA, US
Jianjun Guan - Pittsburgh PA, US
Kazuro Fujimoto - Pittsburgh PA, US
Alejandro Nieponice - Buenos Aires, AR
Lorenzo Soletti - Pittsburgh PA, US
David Vorp - Pittsburgh PA, US
Michael Sacks - Pittsburgh PA, US
Todd Courtney - Odenton MD, US
John Mayer - Wellesley MA, US

A61F 2/06, A61F 2/08, A61F 2/24

623001410, 623014110, 623002120

Described herein are elastomeric materials, and in particular porous biodegradable elastomeric materials which optionally may have microintegrated cells. Also described herein are bioprosthetic devices that can be manufactured using the biodegradable elastomeric materials, non-limiting examples of such devices including pulmonary valves, vocal chords, and blood vessels.

2012015, Jun 21, 2012

Apr 30, 2010

13/265067

Kazuro Lee Fujimoto - Pittsburgh PA, US
Zuwei Ma - Woburn MA, US
Jianjun Guan - Dublin OH, US
William R. Wagner - Gibsonia PA, US

University of Pittsburgh-Of the Commonwealth Syste - Pittsburgh PA

A61K 47/32, C08F 283/02, C08G 81/02, A61K 38/19, A61K 38/02, A61K 31/56, A61K 31/7088, A61K 47/36, A61K 47/42, A61K 38/18, A61K 38/30, C12N 5/071, A61K 35/12, A61P 9/00, A61P 9/10, A61P 31/00, A61P 29/00, A61P 23/00, A61P 7/04, C08F 283/01

424 937, 5263075, 5253282, 5147724, 514 76, 514 11, 514169, 514 44 R, 514 91, 514 86, 435396

Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.

2008000, Jan 10, 2008

Jun 27, 2007

11/823359

Kazuro Fujimoto - Pittsburgh PA, US
Kimimasa Tobita - Wexford PA, US
Jianjun Guan - Pittsburgh PA, US
William Wagner - Wexford PA, US
Bradley Keller - Pittsburgh PA, US

A61M 31/00

604522000, 604057000

Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.