Inventors:
Kavitha P. Raj - Pleasanton CA, US
Jason A. Zell - Dana Point CA, US
Christine E. Mclaren - Irvine CA, US
Eugene W. Gerner - Tucson AZ, US
Jeffrey Jacob - Tucson AZ, US
Assignee:
CANCER PREVENTION PHARMACEUTICALS, INC. - Tucson AZ
CANCER PREVENTION PHARMACEUTICAL, INC - Tucson AZ
THE REGENT OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION - Oakland CA
International Classification:
A61K 31/198, A61K 31/415, A61K 31/192
Abstract:
Controlling exogenous polyamines may be used, in some aspects, as an adjunctive strategy to chemoprevention with polyamine inhibitory agents, for example, anti-carcinoma combination therapies comprising ornithine decarboxylase (ODC) inhibitor and a spermidine/spermine N-acetyltransferase expression agonist, optionally based on a patient's ODC1 promoter genotype. Assessing a tissue polyamine level or tissue polyamine flux may be used in some aspects, for predicting the efficacy of an anti-carcinoma combination therapy comprising, for example, an ornithine decarboxylase (ODC) inhibitor and an agent that modulates the polyamine pathway to reduce overall cellular polyamine content.