KATHRYN SMITH
Nursing at Hotchkiss Rd Ext, New Haven, CT
License number
Connecticut 089162
Issued Date
Jul 7, 2009
Expiration Date
Jul 31, 2017
Category
Registered Nurse
Address
Address
93 Hotchkiss Road Ext, New Haven, CT 06512
Professional information
Owner
Specialties:
Buyer's Agent, Listing Agent, Property Management
Work:
11 Pleasant Hill Rd, Woodbridge 06525
Experience:
42
Gemm Riboswitches, Structure-Based Compound Design With Gemm Riboswitches, And Methods And Compositions For Use Of And With Gemm Riboswitches
US Patent:
2012010, May 3, 2012
Filed:
May 13, 2010
Appl. No.:
13/319246
Inventors:
Scott Allen Strobel - Hamden CT, US
Ronald R. Breaker - Guilford CT, US
Kathryn E. Smith - New Haven CT, US
Ronald R. Breaker - Guilford CT, US
Kathryn E. Smith - New Haven CT, US
International Classification:
A61K 39/395, G06G 7/60, C12Q 1/68, A61P 31/04, C07H 21/04, A61K 31/7088
US Classification:
4241781, 536 231, 514 44 R, 435 613, 703 11
Abstract:
Disclosed is the crystal structure of a GEMM riboswitch from bound to c-di-GMP. The crystal structures show that the RNA binds the ligand within a three helix junction that involves base pairing and extensive base stacking. The symmetric c-di-GMP is recognized asymmetrically with respect to the both the bases and the backbone. Also disclosed are methods of identifying and using compounds and compositions that modulate GEMM riboswitches.