Inventors:
Katherine Weilbaecher - University City MO, US
Suzanne Bakewell - Philadelphia PA, US
International Classification:
A61K 31/55, A61K 31/4747, A61K 31/407, A61K 31/397
US Classification:
514210160, 514212020, 514278000, 514409000
Abstract:
Disclosed are methods for treating, preventing or inhibiting tumor cell metastasis, tumor cell formation, and destroying tumors in a subject comprising administering to the subject in need of such therapy a therapeutically effective amount of an activated aIIbβ3 receptor antagonist and by transplanting affected bone marrow with β3−/−marrow or controlling the expression of β3 integrin in vitro or in vivo. The activated allbβ3 receptor antagonist is preferably a spiro compound.