KARL I HECKER
Engineers in Keene, NH

6397849, Jun 4, 2002

Aug 2, 1999

09/366072

Lyle M. Bowman - Pleasanton CA
James F. Pfeiffer - Oakland CA
Leslie A. Clark - Alameda CA
Karl I. Hecker - Keene NH

InSite Vision Incorporated - Alameda CA

A61B 1900

128898, 604521

Intrascleral injection of a therapeutic or diagnostic material at a location overlying the retina provides a minimally invasive technique for delivering the agent to the posterior segment of the eye. The procedure also allows for close proximity of the material to the targeted site and can be effectively used to treat conditions associated with the posterior segment of the eye, including macular degeneration, vein occlusion, and diabetic retinopathy. The sclera can be used to hold a depot of the material such as for sustained released or as a conduit for propelling material through whereby the material is delivered immediately to the underlying tissues but without physically penetrating the sclera with an instrument or otherwise unreasonably traumatizing the eye.

6378526, Apr 30, 2002

Aug 3, 1998

09/127920

Lyle M. Bowman - Pleasanton CA
James F. Pfeiffer - Oakland CA
Leslie A. Clark - Alameda CA
Karl L. Hecker - Keene NH

InSite Vision, Incorporated - Alameda CA

A61B 1900

128898, 604521

Intrascleral injection of a therapeutic or diagnostic material at a location overlying the retina provides a minimally invasive technique for delivering the agent to the posterior segment of the eye. The procedure also allows for close proximity of the material to the targeted site and can be effectively used to treat conditions associated with the posterior segment of the eye, including macular degeneration, vein occlusion, and diabetic retinopathy.

6299603, Oct 9, 2001

Aug 2, 1999

9/366703

Karl I. Hecker - Keene NH
Leslie A. Clark - Alameda CA
James F. Pfeiffer - Oakland CA
Lyle M. Bowman - Pleasanton CA

A61M 500

604181

The present invention relates to an apparatus and method for using the apparatus for injecting an agent into a tissue, particularly into thin tissues such as the sclera of the eye. The invention provides an apparatus and method for effectively imbedding a needle into a tissue at a predetermined penetration approach angle and penetration distance thereby reducing the risk of penetrating the full thickness of the tissue. The invention includes a support element and a needle guide platform disposed on the support element with an external support surface and a channel extending therethrough and terminating in an aperture at the support surface. A needle disposed in the channel is axially movable along an axis of injection through the channel. The needle is movable from a first retracted position to an extended position corresponding to the penetration distance, along the axis of injection. The axis of injection forms a penetration approach angle of up to about 60. degree.

6309374, Oct 30, 2001

Aug 3, 1998

9/127919

Karl I. Hecker - Keene NH
Leslie A. Clark - Alameda CA
James F. Pfeiffer - Oakland CA
Lyle M. Bowman - Pleasanton CA

Insite Vision Incorporated - Alameda CA

A61M 500

604117

The present invention relates to an apparatus and method for using the apparatus for injecting an agent into a tissue, particularly into thin tissues such as the sclera of the eye. The invention provides an apparatus and method for effectively imbedding a needle into a tissue at a predetermined penetration approach angle and penetration distance thereby reducing the risk of penetrating the full thickness of the tissue. The invention includes a support element and a needle guide platform disposed on the support element with an external support surface and a channel extending therethrough and terminating in an aperture at the support surface. A needle disposed in the channel is axially movable along an axis of injection through the channel. The needle is movable from a first retracted position to an extended position corresponding to the penetration distance, along the axis of injection. The axis of injection forms a penetration approach angle of up to about 60. degree.

2001000, Jul 19, 2001

Feb 14, 2001

09/782206

Karl Hecker - Keene NH, US
Leslie Clark - Alameda CA, US
James Pfeiffer - Oakland CA, US
Lyle Bowman - Pleasanton CA, US

A61M031/00, A61M005/00

604/117000, 604/521000

The present invention relates to an apparatus and method for using the apparatus for injecting an agent into a tissue, particularly into thin tissues such as the sclera of the eye. The invention provides an apparatus and method for effectively imbedding a needle into a tissue at a predetermined penetration approach angle and penetration distance thereby reducing the risk of penetrating the full thickness of the tissue. The invention includes a support element and a needle guide platform disposed on the support element with an external support surface and a channel extending therethrough and terminating in an aperture at the support surface. A needle disposed in the channel is axially movable along an axis of injection through the channel. The needle is movable from a first retracted position to an extended position corresponding to the penetration distance, along the axis of injection. The axis of injection forms a penetration approach angle of up to about 60° with a tangent of the support surface at a point of intersection of the axis of injection with the projection of the support surface across the aperture.