Karen Lynn Meyer
Accountancy at Rhoades Ct, Norman, OK
License number
Colorado 25298
Issued Date
Feb 23, 2007
Renew Date
Jun 1, 2008
Expiration Date
May 31, 2010
Type
Certified Public Accountant
Address
Address
404 Rhoades Ct, Norman, OK 73072
Professional information
Radioiodinated Phospholipid Ether Analogues And Methods Of Using Same
US Patent:
5347030, Sep 13, 1994
Filed:
Feb 10, 1992
Appl. No.:
7/833303
Inventors:
Raymond E. Counsell - Ann Arbor MI
Karen L. Meyer - Norman OK
Susan W. Schwendner - Ann Arbor MI
Terushi Haradahira - Fukuoka, JP
Karen L. Meyer - Norman OK
Susan W. Schwendner - Ann Arbor MI
Terushi Haradahira - Fukuoka, JP
Assignee:
The Board of Regents of The University of Michigan - Ann Arbor MI
International Classification:
C07F 909
US Classification:
558169
Abstract:
Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which, in certain embodiments, is substituted at the 3-position with an alkyl phosphocholine and include a monoiodinated benzoyl side chain substituted at the 2-position in accordance with the general formula: ##STR1## where n= 1-15 ##STR2## m= 0-15; Z=. sup. 123 I,. sup. 125 I, and. sup. 131 I; Y=NH. sub. 2, NR. sub. 2, and NR. sub. 3, and R=alkyl, aralkyl.
Radioiodinated Phosphate Esters
US Patent:
5087721, Feb 11, 1992
Filed:
Oct 22, 1990
Appl. No.:
7/602157
Inventors:
Raymond E. Counsell - Ann Arbor MI
Karen L. Meyer - Norman OK
Susan W. Schwendner - Ann Arbor MI
Terushi Haradahira - Fukuoka, JP
Karen L. Meyer - Norman OK
Susan W. Schwendner - Ann Arbor MI
Terushi Haradahira - Fukuoka, JP
Assignee:
The University of Michigan - Ann Arbor MI
International Classification:
C07F 910, C07F 911
US Classification:
558166
Abstract:
Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which is substituted at the 3-position with an alkyl phosphocholine and include a monoiodinated benzoyl side chain substituted at either the 1- or 2-position. In some embodiments of the invention, the monoiodinated aralkyl side chain may be substituted directly onto alkyl phosphocholine in accordance with general Formula: provided that one and only one of X or Y is a monoiodinated aralkyl ##STR1## where Y=NH. sub. 2, NR. sub. 2, NR. sub. 3, NR. sub. 2 R'
R=alkyl, aralkyl
R'=a monoiodinated aralkyl, such as ##STR2## Z=. sup. 122 I,. sup. 123 I,. sup. 125 I, and. sup. 131 I n=1-15
X=a monoiodinated aralkyl, like R', where n=1-15; or an alkyl, such as --CH. sub. 2 --(CH). sub. m --CH. sub.
Radioiodinated Phospholipid Ether Analogues
US Patent:
5795561, Aug 18, 1998
Filed:
Sep 12, 1994
Appl. No.:
8/304259
Inventors:
Raymond E. Counsell - Ann Arbor MI
Karen L. Meyer - Norman OK
Susan W. Schwendner - Ann Arbor MI
Terushi Haradahira - Fukuoka, JP
Karen L. Meyer - Norman OK
Susan W. Schwendner - Ann Arbor MI
Terushi Haradahira - Fukuoka, JP
Assignee:
The Board of Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 5100, A61M 3614
US Classification:
424 177
Abstract:
Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which, in certain embodiments, is substituted at the 3-position with an alkyl phosphocholine and include a monoiodinated benzoyl side chain substituted at the 2-position in accordance with the general formula: ##STR1## where n=1-15 ##STR2## M=0-15; Z=. sup. 123 I,. sup. 125 I, and. sup. 131 I; Y=NH. sub. 2, NR. sub. 2, and NR. sub. 3, and R=alkyl, aralkyl.