KAREN L MILKIEWICZ
Pharmacy in Exton, PA
License number
Pennsylvania PI115308
Category
Pharmacy
Type
Pharmacy Intern
Address
Address
Exton, PA 19341
Personal information
See more information about KAREN L MILKIEWICZ at radaris.comName
Address
Phone
408 Cadwalader Cir, Exton, PA 19341
428 Concord Ave, Exton, PA 19341
428 Concord, Uwchland, PA 19341
Professional information
Research Scientist Ii At Teva Pharmaceuticals
Location:
Greater Philadelphia Area
Industry:
Pharmaceuticals
Work:
Cephalon, Inc.
Apr 2004 - Dec 2011
-
Research Scientist II in Medicinal Chemistry
3 Dimensional Pharmaceuticals / Johnson and Johnson
- Exton, Pa Feb 2001 - Feb 2004
-
Research Scientist
Education:
State University of New York College at Buffalo 1996 - 2001
Ph.D., Medicinal Chemistry Rutgers, The State University of New Jersey-New Brunswick 1991 - 1996
BS, Pharmacy Continuing Education Credits
NJ Pharmacist License
Ph.D., Medicinal Chemistry Rutgers, The State University of New Jersey-New Brunswick 1991 - 1996
BS, Pharmacy Continuing Education Credits
NJ Pharmacist License
Substituted 1,4-Benzodiazepines And Uses Thereof
US Patent:
2006014, Jul 6, 2006
Filed:
Mar 9, 2006
Appl. No.:
11/371964
Inventors:
Tianbao Lu - Kennett Square PA, US
Louis LaFrance - West Chester PA, US
Daniel Parks - Exton PA, US
Karen Milkiewicz - Exton PA, US
Raul Calvo - Royersford PA, US
Maxwell Cummings - Wayne PA, US
Alexander Kim - Philadelphia PA, US
Bruce Grasberger - Trappe PA, US
Theodore Carver - Downingtown PA, US
Louis LaFrance - West Chester PA, US
Daniel Parks - Exton PA, US
Karen Milkiewicz - Exton PA, US
Raul Calvo - Royersford PA, US
Maxwell Cummings - Wayne PA, US
Alexander Kim - Philadelphia PA, US
Bruce Grasberger - Trappe PA, US
Theodore Carver - Downingtown PA, US
International Classification:
A61K 31/551, C07D 243/12, C07D 243/18
US Classification:
514221000, 540504000, 540505000
Abstract:
The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I:
or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: X and Y are independently —C(O)—, —CH— or —C(S)—; R, R, R, R, R, R, R, R, Rand M arm defined herein; Ris hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl, optionally substituted heteroaralkyl, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonylalkyl, alkylaminocarbonyl or alkylaminocarbonylalkyl; Ris cycloalkyl, aryl, heteroaryl, cycloalkylalkyl, aralkyl, heteroarylalkyl, or a saturated or partially unsaturated heterocycle, each of which is optionally substituted; Ris cycloalkyl: aryl, heteroaryl, a saturated or partially unsaturated heterocycle, cycloalkyl(alkyl), aralkyl or heteroarylalkyl, each of which is optionally substituted; and Ris —(CH)—COR, —(CH)—COM, —(CH)—OH or —(CH)—CONRRn is 0-8, m is 0-8, i is 1-8 and j is 0-8.
Substituted 1,4-Diazepines And Uses Thereof
US Patent:
7115598, Oct 3, 2006
Filed:
Apr 21, 2004
Appl. No.:
10/829040
Inventors:
Tianbao Lu - Churchville PA, US
Karen L. Milkiewicz - Exton PA, US
Pierre Raboisson - Mechelen, BE
Maxwell David Cummings - Wayne PA, US
Raul R. Calvo - Royersford PA, US
Daniel J. Parks - Downingtown PA, US
Juan Jose Marugan Sanchez - Downingtown PA, US
Joan Gushue - Conshohocken PA, US
Kristi Leonard - West Chester PA, US
Karen L. Milkiewicz - Exton PA, US
Pierre Raboisson - Mechelen, BE
Maxwell David Cummings - Wayne PA, US
Raul R. Calvo - Royersford PA, US
Daniel J. Parks - Downingtown PA, US
Juan Jose Marugan Sanchez - Downingtown PA, US
Joan Gushue - Conshohocken PA, US
Kristi Leonard - West Chester PA, US
Assignee:
Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ
International Classification:
C07D 243/14, A61K 31/55
US Classification:
514221, 540506, 540509
Abstract:
The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I:R, R, R, R, R, Rand M are defined herein;X is a bivalent radical of: an alkane, a cycloalkane, an optionally-substituted arene, an optionally-substituted heteroarene, an optionally-substituted arylalkane or an optionally-substituted heteroarylalkane; andRis —COR, —COM, —OH, —NHR, —SOR, —NHCONHR, optionally-substituted amidino or optionally-substituted guanidino;or R—X— is hydrogen or an electron pair;Ris oxygen or —NRR;Ris cycloalkyl, aryl, heteroaryl, cycloalkylalkyl, aralkyl, heteroarylalkyl, or a saturated or partially unsaturated heterocycle, each of which is optionally substituted; andR, Rand Rare independently hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, a saturated or partially unsaturated heterocycle, cycloalkylalkyl, aralkyl or heteroarylalkyl, each of which is optionally substituted; or Rand R, together with the carbon atom to which they are attached form a 3- to 7-membered carbocyclic ring optionally substituted 1 to 3 times with R.
Protein Kinase And Phosphatase Inhibitors And Methods For Designing Them
US Patent:
2003016, Sep 4, 2003
Filed:
Oct 19, 2002
Appl. No.:
10/277217
Inventors:
David Hangauer - Amherst NY, US
Moustafa El-Araby - Plainsboro NJ, US
Karen Milkiewicz - Exton PA, US
Moustafa El-Araby - Plainsboro NJ, US
Karen Milkiewicz - Exton PA, US
International Classification:
A61K031/675, A61K031/5377, A61K031/496, A61K031/47, A61K031/405, C07D413/02, C 07D 4 3/02, C07D209/18
US Classification:
514/080000, 514/254090, 514/233500, 514/307000, 514/419000, 544/143000, 544/373000, 546/023000, 546/146000, 548/414000, 548/494000
Abstract:
The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protein phosphatase inhibitors are provided. The protein kinase or protein phosphatase inhibitors of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, arthrosclerosis, immune system activity, Type II diabetes, and obesity.
Method For Cytoprotection Through Mdm2 And Hdm2 Inhibition
US Patent:
2006018, Aug 24, 2006
Filed:
May 13, 2003
Appl. No.:
10/514338
Inventors:
Holly Koblish - Exton PA, US
Carl Manthey - Downingtown PA, US
Christopher Molly - Yardley PA, US
Tianbao Lu - Churchville PA, US
Daniel Parks - Downingtown PA, US
Louis Lafrance - West Chester PA, US
Karen Milkiewicz - Exton PA, US
Theodore Carver - Charlotte NC, US
Bruce Grasberger - Trappe PA, US
Carl Manthey - Downingtown PA, US
Christopher Molly - Yardley PA, US
Tianbao Lu - Churchville PA, US
Daniel Parks - Downingtown PA, US
Louis Lafrance - West Chester PA, US
Karen Milkiewicz - Exton PA, US
Theodore Carver - Charlotte NC, US
Bruce Grasberger - Trappe PA, US
International Classification:
A61K 38/17, A01N 1/02
US Classification:
514002000, 435002000
Abstract:
The present invention is directed to a method of protecting one or more cells from programmed cytotoxic cell death by contacting the cells with a cytoprotective amount of an MDM2 and/or HDM2 inhibitor. The cytoprotective amount of inhibitor is typically used as a pulsed administration. Useful inhibitors include a class of 1,4-benzodiazepines, which act as inhibitors of MDM2-p53 interactions. The method of the invention can be employed as an adjunct to chemotherapy or radiation therapy. In addition, the methods of the invention can be employed to treat a disease or condition that involves excessive cell death.
Pyridopyrazines And Derivatives Thereof As Alk And C-Met Inhibitors
US Patent:
2010004, Feb 25, 2010
Filed:
Sep 24, 2009
Appl. No.:
12/566362
Inventors:
Bruce D. Dorsey - Ambler PA, US
Karen L. Milkiewicz - Exton PA, US
Douglas A. Pippin - Chester Springs PA, US
Jay P. Theroff - West Chester PA, US
Ted Underiner - Malvern PA, US
Linda Weinberg - Villanova PA, US
Craig A. Zificsak - Downingtown PA, US
Karen L. Milkiewicz - Exton PA, US
Douglas A. Pippin - Chester Springs PA, US
Jay P. Theroff - West Chester PA, US
Ted Underiner - Malvern PA, US
Linda Weinberg - Villanova PA, US
Craig A. Zificsak - Downingtown PA, US
Assignee:
CEPHALON, INC. - Frazer PA
International Classification:
A61K 31/4985, C07D 471/04, C07D 401/14, C07D 403/14
US Classification:
514249, 544350
Abstract:
The present invention provides a compound of Formula Ior a pharmaceutically acceptable salt form thereof, wherein A, L, R, R, R, R, R, R, and X are as defined herein. The compounds of Formula I have ALK and/or c-Met inhibitory activity, and may be used to treat ALK- or c-Met-mediated disorders or conditions.
Pyridopyrazines And Derivatives Thereof As Alk And C-Met Inhibitors
US Patent:
7601716, Oct 13, 2009
Filed:
Apr 30, 2007
Appl. No.:
11/799066
Inventors:
Bruce D. Dorsey - Ambler PA, US
Karen L. Milkiewicz - Exton PA, US
Douglas A. Pippin - Chester Springs PA, US
Jay P. Theroff - West Chester PA, US
Ted Underiner - Malvern PA, US
Linda Weinberg - Villanova PA, US
Craig A. Zificsak - Downingtown PA, US
Karen L. Milkiewicz - Exton PA, US
Douglas A. Pippin - Chester Springs PA, US
Jay P. Theroff - West Chester PA, US
Ted Underiner - Malvern PA, US
Linda Weinberg - Villanova PA, US
Craig A. Zificsak - Downingtown PA, US
Assignee:
Cephalon, Inc. - Frazer PA
International Classification:
A61K 31/4985
US Classification:
514249, 544350, 544405, 544117, 5462681, 548518
Abstract:
The present invention provides a compound of Formula I.
Substituted 1,4-Diazepines And Uses Thereof
US Patent:
2006023, Oct 19, 2006
Filed:
Jun 14, 2006
Appl. No.:
11/452861
Inventors:
Tianbao Lu - Churchville PA, US
Karen Milkiewicz - Exton PA, US
Pierre Raboisson - Mechelen, BE
Maxwell Cummings - Wayne PA, US
Raul Calvo - Royersford PA, US
Daniel Parks - Downingtown PA, US
Louis LaFrance - West Chester PA, US
Juan Marugan Sanchez - Downingtown PA, US
Joan Gushue - Conshohocken PA, US
Kristi Leonard - West Chester PA, US
Karen Milkiewicz - Exton PA, US
Pierre Raboisson - Mechelen, BE
Maxwell Cummings - Wayne PA, US
Raul Calvo - Royersford PA, US
Daniel Parks - Downingtown PA, US
Louis LaFrance - West Chester PA, US
Juan Marugan Sanchez - Downingtown PA, US
Joan Gushue - Conshohocken PA, US
Kristi Leonard - West Chester PA, US
International Classification:
A61K 31/5513, C07D 403/02, C07D 413/02, C07D 243/18
US Classification:
514221000, 540505000
Abstract:
The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I:
or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein:
Pyrrolotriazines As Alk And Jak2 Inhibitors
US Patent:
8471005, Jun 25, 2013
Filed:
Jun 15, 2011
Appl. No.:
13/160890
Inventors:
Henry J. Breslin - Lansdale PA, US
Sankar Chatterjee - Wynnewood PA, US
James L. Diebold - Eagleville PA, US
Bruce D. Dorsey - Ambler PA, US
Derek D. Dunn - Coatesville PA, US
Diane E. Gingrich - Downingtown PA, US
Greg A. Hostetler - Newark DE, US
Robert L. Hudkins - Chester Springs PA, US
Rachael Hunter - Media PA, US
Kurt A. Josef - Radnor PA, US
Joseph Lisko - Alpharetta GA, US
Eugen F. Mesaros - Wallingford PA, US
Karen L. Milkiewicz - Exton PA, US
Gregory R. Ott - Media PA, US
Babu G. Sundar - West Chester PA, US
Jay P. Theroff - West Chester PA, US
Tho Thieu - Ambler PA, US
Rabindranath Tripathy - Churchville PA, US
Theodore L. Underiner - Malvern PA, US
Linda Weinberg - King of Prussia PA, US
Gregory J. Wells - West Chester PA, US
Craig A. Zificsak - Downingtown PA, US
Sankar Chatterjee - Wynnewood PA, US
James L. Diebold - Eagleville PA, US
Bruce D. Dorsey - Ambler PA, US
Derek D. Dunn - Coatesville PA, US
Diane E. Gingrich - Downingtown PA, US
Greg A. Hostetler - Newark DE, US
Robert L. Hudkins - Chester Springs PA, US
Rachael Hunter - Media PA, US
Kurt A. Josef - Radnor PA, US
Joseph Lisko - Alpharetta GA, US
Eugen F. Mesaros - Wallingford PA, US
Karen L. Milkiewicz - Exton PA, US
Gregory R. Ott - Media PA, US
Babu G. Sundar - West Chester PA, US
Jay P. Theroff - West Chester PA, US
Tho Thieu - Ambler PA, US
Rabindranath Tripathy - Churchville PA, US
Theodore L. Underiner - Malvern PA, US
Linda Weinberg - King of Prussia PA, US
Gregory J. Wells - West Chester PA, US
Craig A. Zificsak - Downingtown PA, US
Assignee:
Cephalon, Inc. - Frazer PA
International Classification:
C07D 487/04, C07D 403/12, A61K 31/53, A61K 31/5377, A61P 35/00
US Classification:
544183, 514243
Abstract:
The present invention provides a compound of formula I.
Factor Xa Compounds
US Patent:
7446210, Nov 4, 2008
Filed:
Oct 24, 2005
Appl. No.:
11/257208
Inventors:
Tianbao Lu - Churchville PA, US
Tho V. Thieu - Ambler PA, US
Yu-Kai Lee - Exton PA, US
Daniel J. Parks - Downingtown PA, US
Thomas P. Markotan - Morgantown PA, US
Wenxi Pan - Glenmore PA, US
Karen L. Milkiewicz - Exton PA, US
Mark R. Player - Phoenixville PA, US
Tho V. Thieu - Ambler PA, US
Yu-Kai Lee - Exton PA, US
Daniel J. Parks - Downingtown PA, US
Thomas P. Markotan - Morgantown PA, US
Wenxi Pan - Glenmore PA, US
Karen L. Milkiewicz - Exton PA, US
Mark R. Player - Phoenixville PA, US
Assignee:
Janssen Pharmaceutica N.V. - Beerse
International Classification:
C07D 207/00, C07D 213/00, C07D 231/00, C07D 231/54, C07D 239/02, C07D 241/04, C07D 265/28, C07D 295/00, C07D 487/00
US Classification:
5483581, 544 98, 544298, 544383, 546 1, 5483561, 548400
Abstract:
The present invention is directed to novel compounds of Formula I:.