KAREN ELIZABETH WALLACE
Veterinary in Delaware
License number
Pennsylvania BV008944L
Category
Veterinary Medicine
Type
Temporary Veterinarian
Address
Address
2
Delaware
Newtown Square, PA 19073
Newtown Square, PA 19073
Professional information
Antagonist Antibodies Against Gdf-8 And Uses In Treatment Of Als And Other Gdf-8-Associated Disorders
US Patent:
2007008, Apr 19, 2007
Filed:
Aug 14, 2006
Appl. No.:
11/503062
Inventors:
Frank Walsh - Bryn Mawr PA, US
Margaret Zaleska - Narberth PA, US
David Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Kwak - Ewing NJ, US
Karen Wallace - Newtown Square PA, US
Nicholas Weber - Philadelphia PA, US
Menelas Pangalos - Pennington NJ, US
William Kelley - Reading MA, US
Margaret Zaleska - Narberth PA, US
David Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Kwak - Ewing NJ, US
Karen Wallace - Newtown Square PA, US
Nicholas Weber - Philadelphia PA, US
Menelas Pangalos - Pennington NJ, US
William Kelley - Reading MA, US
International Classification:
A61K 39/395, C07K 16/22
US Classification:
424145100, 530388250
Abstract:
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Antagonist Antibodies Against Gdf-8 And Uses In Treatment Of Als And Other Gdf-8 Associated Disorders
US Patent:
2012000, Jan 5, 2012
Filed:
Feb 18, 2011
Appl. No.:
13/030978
Inventors:
FRANK S. WALSH - BRYN MAWR PA, US
MARGARET M. ZALESKA - NARBERTH PA, US
DAVID S. HOWLAND - YARDLEY PA, US
LIOUDMILA TCHISTIAKOVA - ANDOVER MA, US
RIYEZ KARIM - NORTH ANDOVER MA, US
PAMELA KELLEY - READING MA, US
XIANG-YANG TAN - READING MA, US
SEUNG POON KWAK - EWING NJ, US
KAREN WALLACE - NEWTOWN SQUARE PA, US
NICHOLAS WEBER - MOUNTAINTOP PA, US
MENELAS N. PANGALOS - PENNINGTON NJ, US
WILLIAM KELLEY - READING MA, US
MARGARET M. ZALESKA - NARBERTH PA, US
DAVID S. HOWLAND - YARDLEY PA, US
LIOUDMILA TCHISTIAKOVA - ANDOVER MA, US
RIYEZ KARIM - NORTH ANDOVER MA, US
PAMELA KELLEY - READING MA, US
XIANG-YANG TAN - READING MA, US
SEUNG POON KWAK - EWING NJ, US
KAREN WALLACE - NEWTOWN SQUARE PA, US
NICHOLAS WEBER - MOUNTAINTOP PA, US
MENELAS N. PANGALOS - PENNINGTON NJ, US
WILLIAM KELLEY - READING MA, US
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - PHILADELPHIA PA
WYETH LLC - MADISON NJ
WYETH LLC - MADISON NJ
International Classification:
A61K 39/395, A61P 21/00
US Classification:
4241331, 4241581
Abstract:
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Antagonist Antibodies Against Gdf-8 And Uses In Treatment Of Als And Other Gdf-8 Associated Disorders
US Patent:
2012001, Jan 19, 2012
Filed:
Mar 2, 2011
Appl. No.:
13/038954
Inventors:
Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Karen Wallace - Newtown Square PA, US
Nicholas Weber - Philadelphia PA, US
Menelas N. Pangalos - Pennington NJ, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Karen Wallace - Newtown Square PA, US
Nicholas Weber - Philadelphia PA, US
Menelas N. Pangalos - Pennington NJ, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
C07K 16/00, C12N 5/10, C07H 21/04, C12N 1/19, C12N 15/63, C12P 21/06, C12N 1/21
US Classification:
5303871, 435 696, 435325, 435352, 435358, 435365, 435367, 4352523, 43525231, 43525233, 4352542, 43525421, 43525422, 4353201, 536 2353
Abstract:
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.