Inventors:
Mark Trumbore - Westford MA, US
Roman Rariy - Allston MA, US
Mark Hirsh - Wellesley MA, US
Jane Hirsh - Wellesley MA, US
Julie Saunders - Pocasset MA, US
International Classification:
A61K038/46, A61K033/38, A61K033/36, A61K035/78
US Classification:
424094650, 424618000, 424770000, 424195180, 424672000
Abstract:
Formulations are described for the treatment by enzymatic debridement of wounds and ulcers. The formulations have a clear, transparent composition that allows for easy visualization of the wound, and are non-staining for easy clean up. These formulations can also exhibit increased enzymatic debridement activity, improved post-treatment lubricity and coating occlusivity, and stability. The formulations, optionally containing non-animal source biologics, may be in the form of lotions, aerosols to provide a spray, or a foam. A non-reactive substrate may be used as a composition carrier. A non-aqueous lotion formulation having improved enzymatic activity is provided. The non-aqueous lotion viscosity is adjusted to achieve high enzymatic activity while maintaining the application benefits of high viscosity non-aqueous lotions. The lotion formulation may be delivered in a patch.