Inventors:
Thomas Buelter - Denver CO, US
Andrew Hawkins - Parker CO, US
Peter Meinhold - Denver CO, US
Catherine Asleson Dundon - Englewood CO, US
Aristos Aristidou - Highlands Ranch CO, US
Jun Urano - Aurora CO, US
Doug Lies - Parker CO, US
Matthew Peters - Highland Ranch CO, US
Melissa Dey - Aurora CO, US
Justas Jancauskas - Englewood CO, US
Julie Kelly - Denver CO, US
Ruth Berry - Englewood CO, US
Assignee:
Gevo, Inc. - Englewood CO
International Classification:
C12N 1/00, C12N 15/00, C12N 15/87, C12N 15/74, C12P 7/16, C12P 1/00, C07H 21/04, C07K 1/00
US Classification:
43525411, 4352542, 43525421, 43525422, 43525423, 435160, 435 41, 435440, 435463, 435471, 435476, 536 231, 536 232, 536 237, 536 2374, 530350
Abstract:
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e. g. , acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.