Inventors:
Stephen L. Hoffman - Gaithersburg MD, US
Ruobing Wang - Potomac MD, US
Judith E. Epstein - Kensington MD, US
Joseph D. Cohen - Brussels, BE
Assignee:
GlaxoSmithKline Biologicals S.A. - Rixensart
The United States of America as represented by the Secretary of the Navy - Washington DC
International Classification:
A61K 39/00, A61K 48/00
Abstract:
The invention pertains to methods for protecting against malaria infection by vaccination. The method of the invention involves priming an anti-malaria immune response with a DNA-based vaccine and boosting that response with a protein-based a vaccine. The method of the invention also relates to broadening the resulting immune response by boosting with a protein-based vaccine.