Inventors:
Judie P. Charlton - Morgantown WV
Ivan R. Schwab - Sacramento CA
Assignee:
West Virginia University Research Corporation - Morgantown WV
International Classification:
A61K 3117
Abstract:
A topical ophthalmic preparation utilizing a urea and/or urea derivative or mixtures thereof as the principle active ingredient within a range of about 0. 01% by weight to about 30% by weight and a method of using the same. When applied to a mammalian eye affected with an abnormal ophthalmological surface problem resulting in epithelial cell loss, keratinization, and/or scarring, the present invention will heal epithelial defects, soften keratin, decrease scarring, enhance hydration, and have anti-mucolytic activity. The present invention provides a method for treating ocular conditions such as dryness, noninfectious keratitis, corneal or conjunctival epithelial irregularities, ocular scarring and subjective irritations.