Inventors:
Frank Cuttitta - Adamstown MD, US
Alfredo Martinez - Bethesda MD, US
William G. Stetler-Stevenson - Kensington MD, US
Edward J. Unsworth - Kensington MD, US
Juan M. Saavedra - Bethesda MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 49/00
US Classification:
424 91, 424 111, 424 165, 424 169, 424 92
Abstract:
Methods and compounds are described for regulating blood pressure in a subject. Specific embodiments are methods for reversing vasodilation of blood vessels, by administering to a subject a therapeutically effective amount peptide AM(11-22). The vasoconstrictor can be used for a variety of purposes, including hemostasis or the treatment of shock, for example vasodilatory shock syndromes such as septic shock. Other specific embodiments are methods for reversing vasoconstriction of blood vessels, by administering to a subject a therapeutically effect amount of an inhibitor of AM(11-22), sufficient to reduce hypertension in the subject. Compounds and pharmaceutical compositions are also provided, as are kits.