Inventors:
Bira Arya - Baltimore MD, US
Juan Espinoza - Los Angeles CA, US
Assignee:
The United States of America, as represented by th e Secretary, Dept. of Health and Human Services - Rockville MD
International Classification:
A61K 38/16, C07K 14/00, C07K 19/00, C12N 15/63, C12N 5/071, A61K 49/00, C12N 5/10, C12N 1/00, A61P 35/00
US Classification:
424 91, 530358, 530322, 4353201, 435375, 514 209, 530350, 530324, 435325, 435419, 435243, 514 193
Abstract:
The present invention features compositions and methods that make use of complexes comprising one or more inhibitory nucleic acids and a targeting polypeptide, wherein the targeting polypeptide consists of a cell surface receptor ligand. The compositions can be used in methods of silencing gene expression in a cell, in delivering agents to a target cell, and in treating or preventing a disease or disorder in a subject.