DR. JUAN BERNARDO OCHOA, MD
Medical Practice at Lothrop St, Pittsburgh, PA

2004005, Mar 25, 2004

Mar 12, 2003

10/386131

Augusto Ochoa - New Orleans LA, US
Juan Ochoa - Pittsburgh PA, US
Mircea Popescu - Plainsboro NJ, US
Arnold Zea - Metairie LA, US
Paulo Rodriguez - Metairie LA, US

LSU Medical Center

A61K038/19, A61K031/69, A61K031/198

424/085100, 514/064000, 514/561000, 514/564000, 514/565000

The present invention provides methods and compositions for modulating an immune response by controlling the level of arginase available to a cell, tissue or system. An immune response can be enhanced or depressed by altering the amount of arginine available to a cell, tissue or system through the manipulation of localized or systemic arginine levels using substances which provide arginine to the body and enzymes which break down arginine, such as arginase and nitric oxide synthase. Increasing or decreasing an immune response according to the present invention provides therapeutic treatments for a variety of conditions and diseases. The present invention also provides clinical methods and kits which can measure the strength or resistance to an immune response in a cell, tissue or system based upon the amount of available arginine and enzymes which break down arginine.

2010014, Jun 10, 2010

Sep 2, 2009

12/553019

Michael Raymond Pinsky - Pittsburgh PA, US
Juan Bernardo Ochoa Gautier - Pittsburgh PA, US
Josef Winkler - Wayland MA, US
Gary Wakeford - Canfield OH, US
Sabry Gabriel - Lizella GA, US
Paul Frankhouser - Miami Beach FL, US
Aaron Sandoski - Lincoln MA, US

A61B 1/00

600114

One or more external magnets that are suitable for placement on the back or front of a patient's neck and methods for using the external magnet(s) to guide a feeding tube containing one or more internal magnets through the esophagus are described herein. The external magnet is applied to the back or the front of the patient's neck and the feeding tube is inserted into the patient's nose and advanced within the patient's body. The magnetic field of the external magnet combines with the magnetic field of the internal magnet to produce a sufficient magnetic force to pull or push the feeding tube apparatus against the posterior wall of the esophagus to prevent placement of the stylet in the patient's trachea or windpipe to prevent insertion into the patient's lungs.