JOSHUA MICHAEL DONALDSON
Medical Practice in Lumberton Township, NJ
License number
Pennsylvania MT202020
Category
Medicine
Type
Graduate Medical Trainee
Address
Address
2
Lumberton Township, NJ 08048
Pennsylvania
Pennsylvania
Professional information
Design And Development Of Masked Therapeutic Antibodies To Limit Off-Target Effects; Application To Anti-Egfr Antibodies
US Patent:
2013015, Jun 13, 2013
Filed:
Jul 6, 2012
Appl. No.:
13/542805
Inventors:
John C. Williams - Monrovia CA, US
Ulrich Rodeck - Philadelphia PA, US
Joshua M. Donaldson - Lumberton NJ, US
Csaba Kari - Rosemont PA, US
Ulrich Rodeck - Philadelphia PA, US
Joshua M. Donaldson - Lumberton NJ, US
Csaba Kari - Rosemont PA, US
International Classification:
C07K 16/28
US Classification:
5303873
Abstract:
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a cross-masked mAb heterodimer complex is provided, comprising a first masked mAb, comprising a first signal sequence, a first masking epitope sequence, a first linker that is cleavable by a protease specific to a target tissue, and a first antibody or fragment thereof; and a second masked mAb, comprising a second signal sequence, a second masking epitope sequence, a second linker that is cleavable by a protease specific to a target tissue, and a second antibody or fragment thereof.
Meditopes And Meditope-Binding Antibodies And Uses Thereof
US Patent:
2012030, Nov 29, 2012
Filed:
Apr 10, 2012
Appl. No.:
13/443804
Inventors:
John C. Williams - Monrovia CA, US
David A. Horne - Duarte CA, US
Yuelong Ma - Duarte CA, US
Heng Wei Chang - Foster City CA, US
Joshua Michael Donaldson - Lumberton NJ, US
Cindy Zer - Duarte CA, US
Krzysztof Bzymek - Pasadena CA, US
Kendra Nicole Avery - Pasadena CA, US
Jun Xie - Duarte CA, US
David A. Horne - Duarte CA, US
Yuelong Ma - Duarte CA, US
Heng Wei Chang - Foster City CA, US
Joshua Michael Donaldson - Lumberton NJ, US
Cindy Zer - Duarte CA, US
Krzysztof Bzymek - Pasadena CA, US
Kendra Nicole Avery - Pasadena CA, US
Jun Xie - Duarte CA, US
International Classification:
C07K 16/18, C07K 7/08, C07K 1/14, A61K 39/395, A61K 49/00, C12N 5/071, C07K 7/06, C07K 2/00
US Classification:
424 91, 5303879, 530330, 530329, 530328, 530327, 530326, 530321, 4241391, 4241781, 435331
Abstract:
Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.