Inventors:
Michael Spino - Pickering, CA
Joshua Lawrence Dunaief - Philadelphia PA, US
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - Philadelphia PA
APOTEX TECHNOLOGIES INC. - Toronto ON
International Classification:
A61K 31/4422, A61P 25/02, A61P 27/02, A61P 9/10, A61P 27/06, A61P 27/12
Abstract:
There is provided use of orally available or topically applied deferiprone for prevention of iron-induced eye damage. The use may be for preparation of a medicament or in a method of preventing iron-induced eye damage to an eye of a subject at risk for iron-induced eye damage, the method comprising administering a prophylactically effective amount of deferiprone to the subject. There is also provided the use of deferiprone for treatment of iron-related eye disorders. The use may be for preparation of a medicament or in a method of treatment of damage to an eye of a having eye damage associated with iron, the method comprising topically administering a therapeutically effective amount of deferiprone to the subject.