JOSEPH THOMAS RUBINO
Pharmacy in Towaco, NJ
License number
Pennsylvania RP029647L
Category
Pharmacy
Type
Pharmacist
Address
Address
2
Towaco, NJ 07082
Pennsylvania
Pennsylvania
Personal information
See more information about JOSEPH THOMAS RUBINO at radaris.comName
Address
Phone
57 Street Rd, Newtown Sq, PA 19073
609A Shaler Blvd, Ridgefield, NJ 07657
50 Cedar Hill Ave, Belleville, NJ 07109
61 Sprague St, Wilmerding, PA 15148
67 9Th St, Wyoming, PA 18644
Professional information
Calicheamicin Derivative-Carrier Conjugates
US Patent:
2004019, Sep 30, 2004
Filed:
Nov 3, 2003
Appl. No.:
10/699874
Inventors:
Arthur Kunz - New City NY, US
Justin Moran - Valley Cottage NY, US
Joseph Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Vidunas - Middletown NY, US
John Simpson - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John DiJoseph - Woodbridge NJ, US
Mark Ruppen - Garnerville NY, US
Nitin Damle - Upper Saddle River NJ, US
Paul Robbins - Derwood MD, US
Andrew Popplewell - Staines, GB
Justin Moran - Valley Cottage NY, US
Joseph Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Vidunas - Middletown NY, US
John Simpson - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John DiJoseph - Woodbridge NJ, US
Mark Ruppen - Garnerville NY, US
Nitin Damle - Upper Saddle River NJ, US
Paul Robbins - Derwood MD, US
Andrew Popplewell - Staines, GB
Assignee:
Wyeth Holdings Corporation - Madison NJ
International Classification:
C07K016/46, C07K014/47
US Classification:
530/391100, 530/403000, 530/409000
Abstract:
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
Calicheamicin Derivative-Carrier Conjugates
US Patent:
8153768, Apr 10, 2012
Filed:
May 2, 2003
Appl. No.:
10/428894
Inventors:
Arthur Kunz - New City NY, US
Justin Keith Moran - Valley Cottage NY, US
Joseph Thomas Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Joseph Vidunas - Middletown NY, US
John McLean Simpson - Upper Nyack NY, US
Paul David Robbins - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John Francis DiJoseph - Woodbridge NJ, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Andrew George Popplewell - Staines, GB
Justin Keith Moran - Valley Cottage NY, US
Joseph Thomas Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Joseph Vidunas - Middletown NY, US
John McLean Simpson - Upper Nyack NY, US
Paul David Robbins - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John Francis DiJoseph - Woodbridge NJ, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Andrew George Popplewell - Staines, GB
Assignee:
Wyeth Holdings Corporation - Madison NJ
International Classification:
C07K 16/00, C07K 17/00, C07K 16/28
US Classification:
5303911, 5303917, 5303919, 530409
Abstract:
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
Parenteral Cci-779 Formulations Containing Cosolvents, An Antioxidant, And A Surfactant
US Patent:
8026276, Sep 27, 2011
Filed:
Jul 25, 2003
Appl. No.:
10/626943
Inventors:
Joseph T. Rubino - Towaco NJ, US
Victoria Siskavich - Lyon Mountain NY, US
Maureen M. Harrison - Sugar Loaf NY, US
Pooja Gandhi - Highland Mills NY, US
Victoria Siskavich - Lyon Mountain NY, US
Maureen M. Harrison - Sugar Loaf NY, US
Pooja Gandhi - Highland Mills NY, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A61K 31/435
US Classification:
514450, 514454, 514338, 514294, 514885, 514970
Abstract:
Parenteral formulations of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl) -2-methylpropionic acid (CCI-779) are provided. One parenteral formulation contains CCI-779, an alcoholic co-solvent, and an antioxidant. Another parenteral formulation contains CCI-779, an alcoholic solvent, an antioxidant, a diluent solvent, and a surfactant. Processes for preparing parenteral CCI-779 formulations using a co-solvent concentrate are also provided.
Calicheamicin Conjugates
US Patent:
2009010, Apr 23, 2009
Filed:
Aug 4, 2008
Appl. No.:
12/221551
Inventors:
Arthur Kunz - New City NY, US
Justin Keith Moran - Valley Cottage NY, US
Joseph Thomas Rubino - Towaco NJ, US
Neera Jain - Lexington MA, US
Erwin Raymond Arsene Boghaert - Monroe NY, US
Philip Ross Hamann - Thiells NY, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Eugene Vidunas - Middletown NY, US
Lyka Kalyandrug - Congers NY, US
Justin Keith Moran - Valley Cottage NY, US
Joseph Thomas Rubino - Towaco NJ, US
Neera Jain - Lexington MA, US
Erwin Raymond Arsene Boghaert - Monroe NY, US
Philip Ross Hamann - Thiells NY, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Eugene Vidunas - Middletown NY, US
Lyka Kalyandrug - Congers NY, US
Assignee:
Wyeth - Madison NJ
International Classification:
C07K 16/00
US Classification:
5303919
Abstract:
Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
Control Of Cci-779 Dosage Form Stability Through Control Of Drug Substance Impurities
US Patent:
2007014, Jun 21, 2007
Filed:
Dec 19, 2006
Appl. No.:
11/642029
Inventors:
Joseph Rubino - Towaco NJ, US
Pooja Gandhi - Highland Mills NY, US
Lynn Phelan - Lake Hiawatha NJ, US
Pooja Gandhi - Highland Mills NY, US
Lynn Phelan - Lake Hiawatha NJ, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/4745, A61K 31/355, A61K 31/375
US Classification:
514291000, 514458000, 514474000
Abstract:
A method of preparing a rapamycin composition having increased potency is provided. The method involves selecting a rapamycin compound having less than 1.5% oxidative and hydrolytic rapamycin impurities and formulating the selected rapamycin with an antioxidant and optional excipients.
Calicheamicin Conjugates
US Patent:
2006000, Jan 5, 2006
Filed:
Mar 15, 2005
Appl. No.:
11/080587
Inventors:
Arthur Kunz - New City NY, US
Justin Moran - Valley Cottage NY, US
Joseph Rubino - Towaco NJ, US
Neera Jain - Monroe NY, US
Erwin Raymond Boghaert - Monroe NY, US
Philip Hamann - Thiells NY, US
Mark Ruppen - Garnerville NY, US
Nitin Damle - Upper Saddle River NJ, US
Eugene Vidunas - Middletown NY, US
Justin Moran - Valley Cottage NY, US
Joseph Rubino - Towaco NJ, US
Neera Jain - Monroe NY, US
Erwin Raymond Boghaert - Monroe NY, US
Philip Hamann - Thiells NY, US
Mark Ruppen - Garnerville NY, US
Nitin Damle - Upper Saddle River NJ, US
Eugene Vidunas - Middletown NY, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 39/395, C07K 16/46
US Classification:
424178100, 530391100
Abstract:
Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
Cci-779 Concentrate Formulations
US Patent:
8299116, Oct 30, 2012
Filed:
Aug 10, 2011
Appl. No.:
13/206641
Inventors:
Joseph T Rubino - Towaco NJ, US
Victoria Siskavich - Lyon Mountain NY, US
Maureen M Harrison - Sugar Loaf NY, US
Pooja Gandhi - Highland Mills NY, US
Victoria Siskavich - Lyon Mountain NY, US
Maureen M Harrison - Sugar Loaf NY, US
Pooja Gandhi - Highland Mills NY, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A61K 31/435
US Classification:
514450, 514454, 514338, 514294, 514885, 514970
Abstract:
This invention provides CCI-779 cosolvent concentrates which are useful in preparing a parenteral formulation of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) following admixture with a diluent.
Cci-779 Lyophilized Formulations
US Patent:
2005002, Jan 27, 2005
Filed:
Jul 19, 2004
Appl. No.:
10/894210
Inventors:
Joseph Rubino - Towaco NJ, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K031/4745
US Classification:
514291000
Abstract:
Lyophilized CCI-779 formulations composed of CCI-779 and t-butyl alcohol or ethanol are described. Also provided are solutions useful in preparing said lyophilized CCI-779 formulations, methods of reconstituting same, and uses for same.