Inventors:
Guochuan Tsai - Cambridge MA
Joseph Coyle - Belmont MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K 3166
Abstract:
The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimers Disease, autism, depression, benign forgetfulness, childhood learning disorders, close head injury, and attention deficit disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) a therapeutically effective amount of D-alanine (or a modified form thereof), provided that the composition is substantially free of D-cycloserine, and/or (ii) D-serine (or a modified form thereof), and/or (iii) 105 to 500 mg of D-cycloserine (or a modified form thereof), and/or (iv) N-methylglycine (or a modified form thereof).