Inventors:
Joseph Arena - Eagleville PA, US
Doris Cully - Scotch Plains NJ, US
Scott Feighner - Highlands NJ, US
Andrew Howard - Park Ridge NJ, US
Paul Liberator - Holmdel NJ, US
James Schaeffer - Westfield NJ, US
Leonardus Van Der Ploeg - Scotch Plains NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C12P021/02, C07K014/72, C07H021/04, C12N005/06
US Classification:
435/069100, 435/320100, 435/353000, 530/350000, 536/023500
Abstract:
Human, swine and rat growth hormone secretagogue receptors have been isolated, cloned and sequenced. Growth hormone secretagogue receptors are new members of the G-protein family of receptors. The growth hormone secretagogue receptors may be used to screen and identify compounds which bind to the growth hormone secretagogue receptor. Such compounds may be used in the treatment of conditions which occur when there is a shortage of growth hormone, such as observed in growth hormone deficient children, elderly patients with musculoskeletal impairment and recovering from hip fracture and osteoporosis.