Inventors:
Dominic P. Behan - San Diego CA
Derek T. Chalmers - Solana Beach CA
Chen W. Liaw - San Diego CA
Joseph F. Russo - San Diego CA
William J. Thomsen - Del Mar CA
Assignee:
Arena Pharmaceuticals, Inc. - San Diego CA
International Classification:
C07K 2104
US Classification:
536 231, 536 235, 4353201, 435325, 4352523, 435 691, 4351723, 435 71, 530300, 530350
Abstract:
Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT and human 5-HT receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT receptors. Yet further disclosed is a new class of compounds which act at the 5HT receptors.