DR. JOSEPH RUSSELL MADSEN, M.D.
Medical Practice at Longwood Ave, Boston, MA

6547734, Apr 15, 2003

Oct 30, 2001

10/012774

Joseph R. Madsen - Newton MA
George A. Taylor - Wellesley MA

Childrens Medical Center Corporation - Boston MA

A61B 800

600438

Apparatus and methods are disclosed for non-invasive measurement of blood velocity in otherwise inaccessible body regions, and for correlating such measurements with externally applied pressure to detect and/or assess diseases or physiological abnormalities. The blood velocity measurements can be based on the Doppler shift that occurs when an ultrasonic wave is scattered by moving particles within the blood. Since blood vessels have elastic walls, the geometry of the walls, and therefore the flow dynamics, will change in response to elevated in vivo pressure. The change in resistance to blood flow resulting from these pressure induced changes to the blood vessel wall geometry can provide a measure of intracranial pressure, ophthalmic pressure or various other body conditions that affect blood perfusion. Since the blood vessel wall geometry changes rapidly in response to such changes in pressure, the invention can be used to detect hydrocephalus, retinopathy, papilledema and other physiological abnormalities manifested by pressure changes.

6383160, May 7, 2002

Apr 29, 1999

09/301997

Joseph R. Madsen - Newton MA

Childrens Medical Center Corporation - Boston MA

A61M 500

604 10, 60416703

Variable anti-siphon devices are disclosed for use in cerebrospinal fluid shunt systems. Such devices can include a housing with an internal chamber, an adjustable barrier separating the chamber into two cavities, and a diaphragm that seats itself against the adjustable barrier with a seating force that is proportional to the pressure differential across it. The adjustable barrier advantageously allows the level of anti-siphon protection to be modified. In one embodiment, the height of the adjustable barrier may be varied. In another embodiment, the barrier is moved longitudinally within the internal chamber to vary the volume of each chamber.

6309354, Oct 30, 2001

Jul 11, 2000

9/613648

Joseph R. Madsen - Newton MA
George A. Taylor - Wellesley MA

Children's Medical Center Corporation - Boston MA

A61B 8010

600438

Apparatus and methods are disclosed for non-invasive measurement of blood velocity in otherwise inaccessible body regions, and for correlating such measurements with externally applied pressure to detect and/or assess diseases or physiological abnormalities. The blood velocity measurements can be based on the Doppler shift that occurs when an ultrasonic wave is scattered by moving particles within the blood. Since blood vessels have elastic walls, the geometry of the walls, and therefore the flow dynamics, will change in response to elevated in vivo pressure. The change in resistance to blood flow resulting from these pressure induced changes to the blood vessel wall geometry can provide a measure of intracranial pressure, ophthalmic pressure or various other body conditions that affect blood perfusion. Since the blood vessel wall geometry changes rapidly in response to such changes in pressure, the invention can be used to detect hydrocephalus, retinopathy, papilledema and other physiological abnormalities manifested by pressure changes.

6091979, Jul 18, 2000

Jul 7, 1998

9/111328

Joseph R. Madsen - Newton MA

Children's Medical Center Corporation - Boston MA

A61B 5042

600377

Electrodes arrays for monitoring in vivo electrical activity are disclosed. The arrays include a plurality of electrode contact pads in a predetermined spatial orientation held together by a structural matrix material that is preferably bioresorbable. The electrode pads are connected via lead wires to monitoring, analysis, and recording apparatus. The electrode arrays can be individually prepared, and configured (e. g. , by irregular spacing between the electrode contact pads) to conform to the region undergoing analysis. Because the matrix material is substantially resorbed in the course of the protocol, the individual electrode cables will no long be attached to each other (or in the case of branching electrodes, the branches will no longer be fixed in position). In either instance, the electrode cables (or trunk and branches) can be removed without a second major operation.

6086533, Jul 11, 2000

Jun 12, 1998

9/097067

Joseph R. Madsen - Newton MA
George A. Taylor - Wellesley MA

Children's Medical Center Corporation - Boston MA

A61B 800

600438

Apparatus and methods are disclosed for non-invasive measurement of blood velocity in otherwise inaccessible body regions, and for correlating such measurements with externally applied pressure to detect and/or assess diseases or physiological abnormalities. The blood velocity measurements can be based on the Doppler shift that occurs when an ultrasonic wave is scattered by moving particles within the blood. Since blood vessels have elastic walls, the geometry of the walls, and therefore the flow dynamics, will change in response to elevated in vivo pressure. The change in resistance to blood flow resulting from these pressure induced changes to the blood vessel wall geometry can provide a measure of intracranial pressure, ophthalmic pressure or various other body conditions that affect blood perfusion. Since the blood vessel wall geometry changes rapidly in response to such changes in pressure, the invention can be used to detect hydrocephalus, retinopathy, papilledema and other physiological abnormalities manifested by pressure changes.

2006007, Apr 13, 2006

Sep 23, 2005

11/234355

Joseph Madsen - Newton MA, US
James Goldie - Lexington MA, US
Kristen Choppy - Somerville MA, US
Thieu Truong - North Easton MA, US

G01B 3/34, G01B 5/02, A61B 5/107

033512000, 600587000

The invention relates to apparatus and methods for measuring a human head. The apparatus disclosed herein involve the use of linear rulers, or rotating contacting members, coupled to a support member. The apparatus disclosed herein can be positioned on a human head, using the methods disclosed herein, to determine the outer contour of the head. Such a measurement can aid in the diagnosis and monitoring of various abnormalities of the human head, including plagiocephaly.