Inventors:
Wai-Ping Leung - San Diego CA
Trudy Christiansen-Weber - San Diego CA
Joseph R. Voland - San Diego CA
Per A. Peterson - Bedminster NJ
Assignee:
Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ
International Classification:
A01K 67027, C12N 1500, C12N 1563, C12N 1590
Abstract:
A transgenic mouse with alterations in an abc1 gene is prepared by introduction of an altered abc1 gene into a host animal. The resulting transgenic mice do not produce functional ABC1 protein molecules. Cells and cell lines derived from these animals also contain the altered abc1 gene.