JOSEPH ROBERT HOLTMAN, MD
Osteopathic Medicine at Rose St, Lexington, KY

2008013, Jun 5, 2008

Nov 10, 2006

11/558782

Joseph R. Holtman - Lexington KY, US
Peter A. Crooks - Nicholasville KY, US

A61K 31/439, A61P 29/00, A61P 25/00, A61K 31/135, A61K 31/445, A61K 31/4355

514282, 514646, 514329, 514326, 514281, 514183

The present invention relates to methods of alleviating pain with the administration of norketamine with a narcotic. More particularly, the invention provides a method of alleviating pain through the administration of a dose of norketamine, which, if administered alone would provide sub-optimal analgesic relief, yet provides analgesic relief when combined with a narcotic. In some embodiments, the combination of norketamine with a narcotic, further allows for the administration of a dose narcotic, which would be sub-optimal if used alone, but provides adequate pain relief in combination with norketamine. The invention relates to self-management of pain on an outpatient basis comprising administering via conventional routes, including transdermal, nasal, rectal, oral, transmucosal, intravenous, intramuscular, and other routes, one or more doses of norketamine/opioid compositions effective to alleviate pain to a subject suffering from pain. Uses of norketamine/opioid compositions would also apply, to treating headaches, drug abuse, mood and anxiety disorders, as well as other, neuropsychiatric disorders, both motoric and cognitive, such as Alzheimer's disease, Parkinson's syndrome, which are thought to be caused by neurodegeneration.

2010017, Jul 8, 2010

Dec 7, 2009

12/632339

Joseph R. HOLTMAN - Lexington KY, US
Peter A. Crooks - Nicholasville KY, US
Linda P. Dwoskin - Lexington KY, US
J. Michael McIntosh - Salt Lake City UT, US

University of Kentucky Research Foundation - Lexington KY
University of Utah - Salt Lake City UT

A61K 31/472, A61K 31/03, A61K 31/44, A61P 29/00

514308, 514751, 514332, 514333

Provided are methods of modulating, treating, reversing and/or preventing pain using tetrakis quaternary ammonium compounds, especially regarding pain of central and/or peripheral origin and/or pain which is nociceptive, neuropathic, somatic, visceral, and/or inflammatory in nature.

2008017, Jul 24, 2008

Oct 10, 2007

11/973818

Joseph R. Holtman - Lexington KY, US
Peter A. Crooks - Nicholasville KY, US
Harpreet K. Dhooper - Lexington KY, US

University of Kentucky - Lexington KY

C07D 489/00, A61K 31/439

514282, 546 44

Compounds including an opioid, and a cannabinoid covalently bound by a linker; pharmaceutical formulations including codrugs; methods of manufacture as well as methods of treatment are disclosed.

2011011, May 12, 2011

Mar 27, 2009

12/934946

Joseph R. Holtman - Lexington KY, US
Peter A. Crooks - Nicholasville KY, US
Ujjwal Chakraborty - Lexington KY, US

University of Kentucky Research Foundation A144 ASTeCC Building - Lexington KY

A61K 31/485, C07D 489/02, C07D 221/28, C07C 271/06, A61K 31/27, C07D 489/12, A61P 25/04, C07D 489/08

514282, 546 44, 546 74, 514289, 560 27, 514506, 546 39, 514279, 546 45

The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and ketamine or norketamine which have been combined to form a single chemical codrug entity. When the codrug is administered it produces a synergistic analgesic response to pain.

2011011, May 12, 2011

Mar 27, 2009

12/934861

Joseph R. Holtman - Lexington KY, US
Peter A. Crooks - Nicholasville KY, US
Ujjwal Chakraborty - Lexington KY, US

University of Kentucky Research Foundation - Lexington KY

A61K 31/485, C07D 489/02, C07D 401/14, C07D 489/12, C07D 401/04, A61K 31/465, A61P 25/04

514282, 546 44, 546 45, 546 74, 546 39, 5462764, 514343, 514289, 514279

The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and nornicotine which have been combined to form a single chemical codrug entity. When the codrug is administered it produces a synergistic analgesic response to pain.

2010012, May 13, 2010

Oct 9, 2009

12/576300

Joseph R. HOLTMAN - Lexington KY, US
Peter A. CROOKS - Nicholasville KY, US
Linda P. DWOSKIN - Lexington KY, US
J. Michael MCINTOSH - Salt Lake City UT, US

University of Kentucky Research Foundation - Lexington KY

A61K 31/4709, A61P 25/00

514314

Provided are tris-quaternary ammonium compounds which are modulators of nociception and pain.

2011016, Jul 7, 2011

Sep 13, 2010

12/880591

Joseph R. HOLTMAN - Lexington KY, US
Peter A. Crooks - Lexington KY, US
Linda P. Dwoskin - Lexington KY, US
J. Michael McIntosh - Salt Lake City UT, US
Elzbieta Pogonowska Wala - Lexington KY, US

University of Kentucky Research Foundation - Lexington KY

A61K 31/4725, A61K 31/444, A61K 31/4709, A61K 31/03, A61K 31/047, A61P 29/00

514308, 514332, 514333, 514314, 514752, 514730

Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.